Developing Superselective Homobivalent Ligands Differentiating Membrane Antigen Density by Exploring the Spatial Limit of the Bivalency on Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.5c04844
Abstract: Developing highly selective molecular recognition tools to distinguish cancer cells from healthy cells remains a considerable challenge. Here, we engineered a series of homobivalent ligands by positioning monomeric aptamers at the 3'-termini of DNA duplex… read more here.
Keywords: homobivalent ligands; membrane antigen; antigen density;
Impact of Antigen Density on the Binding Mechanism of IgG Antibodies
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DOI: 10.1038/s41598-017-03942-z
Abstract: The density and distribution pattern of epitopes at the surface of pathogens have a profound impact on immune responses. Although multiple lines of evidence highlight the significance of antigen surface density for antibody binding, a… read more here.
Keywords: impact antigen; binding mechanism; density; recognition ... See more keywords
PI-RADS v2.1 Combined With Prostate-Specific Antigen Density for Detection of Prostate Cancer in Peripheral Zone
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.861928
Abstract: Purpose To evaluate the diagnostic performance of combining the Prostate Imaging Reporting and Data System (PI-RADS) scoring system v2.1 with prostate-specific antigen density (PSAD) to detect prostate cancer (PCa). Methods A total of 266 participants… read more here.
Keywords: prostate specific; prostate cancer; prostate; specific antigen ... See more keywords