Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes
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DOI: 10.1038/s41591-018-0203-7
Abstract: Identifying immunodominant T cell epitopes remains a significant challenge in the context of infectious disease, autoimmunity, and immuno-oncology. To address the challenge of antigen discovery, we developed a quantitative proteomic approach that enabled unbiased identification… read more here.
Keywords: antigen discovery; immunodominance; restricted epitopes; cell ... See more keywords
Antigen Discovery in Circulating Extracellular Vesicles From Plasmodium vivax Patients
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DOI: 10.3389/fcimb.2021.811390
Abstract: Plasmodium vivax is the most widely distributed human malaria parasite with 7 million annual clinical cases and 2.5 billion people living under risk of infection. There is an urgent need to discover new antigens for… read more here.
Keywords: vivax; extracellular vesicles; vivax patients; discovery circulating ... See more keywords
A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma—A Proof of Antigen Discovery Feasibility in Three Patients
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01832
Abstract: Despite the promising therapeutic effects of immune checkpoint blockade (ICB), most patients with solid tumors treated with anti-PD-1/PD-L1 monotherapy do not achieve objective responses, with most tumor regressions being partial rather than complete. It is… read more here.
Keywords: antigen discovery; autologous dendritic; standard care; vaccine ... See more keywords
Contribution of Capillary Zone Electrophoresis Hyphenated with Drift Tube Ion Mobility Mass Spectrometry as a Complementary Tool to Microfluidic Reversed Phase Liquid Chromatography for Antigen Discovery
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113350
Abstract: The discovery of new antigens specific to multiple myeloma that could be targeted by novel immunotherapeutic approaches is currently of great interest. To this end, it is important to increase the number of proteins identified… read more here.
Keywords: drift tube; zone electrophoresis; capillary zone; antigen discovery ... See more keywords