Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers
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DOI: 10.7554/elife.55678
Abstract: Affinity maturation is a complex dynamical process allowing the immune system to generate antibodies capable of recognizing antigens. We introduce a model for the evolution of the distribution of affinities across the antibody population in… read more here.
Keywords: modeling effect; antigen dosage; quantitative modeling; affinity ... See more keywords