Enhanced TLR5-denpendent migration and activation of antigen-loaded airway dendritic cells by flagellin.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad030
Abstract: Toll-like receptor 5 (TLR5) agonist flagellin is an effective mucosal adjuvant via intranasal (i.n.) administration. Previous studies demonstrated that the mucosal adjuvanticity of flagellin depends on TLR5 signaling of airway epithelial cells. Since dendritic cells… read more here.
Keywords: antigen loaded; enhanced tlr5; activation; flagellin enhanced ... See more keywords
Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti–PD-1 and Anti–PD-L1 Treatment in a Checkpoint Refractory Melanoma Model
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0540
Abstract: In mice with checkpoint-refractory melanoma, antigen-loaded EVs induce antitumor immune responses. Prophylactic immunization with EVs sensitizes tumors to anti–PD-L1 and leads to prolonged survival, indicating potential use of EVs against checkpoint-refractory cancers. read more here.
Keywords: checkpoint refractory; antigen loaded; refractory melanoma;