Biocompatible single-chain polymer nanoparticles loaded with an antigen mimetic as potential anticancer vaccine
Sign Up to like & getrecommendations! Published in 2018 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.8b00052
Abstract: The “pancarcinoma” Tn antigen (αGalNAc-O-Ser/Thr) is a tumor-associated carbohydrate antigen (TACA) overexpressed on the surface of cancer cells and suitable target for anticancer vaccines. However, TACAs commonly show weak immunogenicity, low in vivo stability, and… read more here.
Keywords: antigen mimetic; chain polymer; biocompatible single; anticancer ... See more keywords
Mucin 1 antigen mimetic functionalized mannosylated peptide nanofibers for antigen uptake and immune modulation.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm00304k
Abstract: In this work, immune modulation of monocyte-derived dendritic cells was studied using in vitro cell culture and organ-on-chip models. Self-assembled mannosylated peptide nanofibers were prepared and integrated with the MUC1 TnThr mimetic Tn-MIM, to stimulate… read more here.
Keywords: antigen; peptide nanofibers; immune modulation; antigen mimetic ... See more keywords