mRNA Delivery System for Targeting Antigen‐Presenting Cells In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201800335
Abstract: The encapsulation of mRNA in nanosystems as gene vaccines for immunotherapy purposes has experienced an exponential increase in recent years. Despite the many advantages envisaged within these approaches, their application in clinical treatments is still… read more here.
Keywords: delivery system; presenting cells; mrna delivery; system targeting ... See more keywords
Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202101190
Abstract: The growing enthusiasm for cancer immunotherapies and adoptive cell therapies has prompted increasing interest in biomaterials development mimicking natural antigen-presenting cells (APCs) for T-cell expansion. In contrast to conventional bottom-up approaches aimed at layering synthetic… read more here.
Keywords: intracellular hydrogelation; dendritic cells; antigen; antigen presenting ... See more keywords
Surface‐Functionalized Microgels as Artificial Antigen‐Presenting Cells to Regulate Expansion of T Cells
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202309860
Abstract: Artificial antigen‐presenting cells (aAPCs) are currently used to manufacture T cells for adoptive therapy in cancer treatment, but a readily tunable and modular system can enable both rapid T cell expansion and control over T… read more here.
Keywords: antigen; presenting cells; surface; expansion ... See more keywords
Tissue-specific antigen-presenting cells contribute to distinct phenotypes of allergy.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202249980
Abstract: Antigen presenting cells (APCs) are critical cells bridging innate and adaptive immune responses by taking up, processing, and presenting antigens to naïve T cells. At steady state, APCs thus control both tissue homeostasis and the… read more here.
Keywords: antigen presenting; presenting cells; specific antigen; tissue specific ... See more keywords
Human repair‐related Schwann cells adopt functions of antigen‐presenting cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24257
Abstract: The plastic potential of Schwann cells (SCs) is increasingly recognized to play a role after nerve injury and in diseases of the peripheral nervous system. In addition, reports on the interaction between SCs and immune… read more here.
Keywords: repair related; antigen presenting; schwann cells; presenting cells ... See more keywords
Identification of genes and pathways in human antigen‐presenting cell subsets in response to polio vaccine by bioinformatical analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25514
Abstract: Polio eradication has been achieved in the world except for three countries due to the widespread use of the inactivated poliovirus vaccine (IPV) and the live‐attenuated oral poliovirus vaccine. Following polio eradication, the IPV would… read more here.
Keywords: vaccine; antigen presenting; human antigen; polio vaccine ... See more keywords
Identification of Antigen Presenting Cell Subsets Supporting Human Tfh Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_11
Abstract: CD4+ T follicular helper (Tfh) cells are essential for initiating and regulating efficient humoral responses in secondary lymphoid organs. Tfh polarization and differentiation is driven by multiple stimuli delivered by antigen presenting cells (APCs). APCs… read more here.
Keywords: human tfh; identification antigen; tfh; biology ... See more keywords
Imaging the Interactions Between B Cells and Antigen-Presenting Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7474-0_10
Abstract: In vivo, B cells are often activated by antigens that are displayed on the surface of antigen-presenting cells (APCs). Binding of membrane-associated antigens to the B cell receptor (BCR) causes rapid cytoskeleton-dependent changes in the… read more here.
Keywords: imaging interactions; bcr; presenting cells; model antigens ... See more keywords
Biomimetic biodegradable artificial antigen presenting cells synergize with PD-1 blockade to treat melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2016.11.038
Abstract: Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and… read more here.
Keywords: melanoma; biomimetic biodegradable; blockade; artificial antigen ... See more keywords
Mannosylated Polycations Target CD206+ Antigen-Presenting Cells and Mediate T-Cell-Specific Activation in Cancer Vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00993
Abstract: Immunotherapy is deemed one of the most powerful therapeutic approaches to treat cancer. However, limited response and tumor specificity are still major challenges to address. Herein, mannosylated polycations targeting mannose receptor- are developed as vectors… read more here.
Keywords: cell; antigen presenting; activation; presenting cells ... See more keywords
Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Nano Letters"
DOI: 10.1021/acs.nanolett.2c00819
Abstract: Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect… read more here.
Keywords: desensitization autoreactive; antigen presenting; type diabetes; artificial antigen ... See more keywords