A personal retrospective on the mechanisms of antigen processing
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-01098-2
Abstract: My intention here is to describe the history of the molecular aspects of the antigen processing field from a personal perspective, beginning with the early identification of the species that we now know as MHC… read more here.
Keywords: antigen processing; class; personal retrospective; retrospective mechanisms ... See more keywords
Aberrant antigen processing and presentation: Key pathogenic factors leading to immune activation in Ankylosing spondylitis.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunopathology"
DOI: 10.1007/s00281-020-00833-w
Abstract: The strong association of HLA-B*27 with ankylosing spondylitis (AS) was first reported nearly 50 years ago. However, the mechanistic link between HLA-B*27 and AS has remained an enigma. While 85-90% of AS patients possess HLA-B*27,… read more here.
Keywords: processing presentation; antigen processing; ankylosing spondylitis; hla ... See more keywords
Antigen processing and presentation.
Sign Up to like & getrecommendations! Published in 2019 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2019.07.005
Abstract: Dendritic cells are at the center of immune responses. They are defined by their ability to sense the environment, take up and process antigen, migrate to secondary lymphoid organs, where they present antigens to the… read more here.
Keywords: processing presentation; antigen processing; antigen; biology ... See more keywords
Natural spleen cell ligandome in transporter antigen processing (TAP)-deficient mice.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00416
Abstract: Peptides generated by proteases in the cytosol must be translocated to endoplasmic reticulum lumen by the transporter associated with antigen processing (TAP) prior to their assembly with major histocompatibility complex (MHC) class I molecules. Non-functional… read more here.
Keywords: antigen processing; tap deficient; mhc; tap independent ... See more keywords
Antigen processing movers and shakers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.1038/s41589-018-0106-4
Abstract: Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex. read more here.
Keywords: processing movers; movers shakers; antigen processing; biology ... See more keywords
Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c7bm00244k
Abstract: Understanding the effects of magnetic iron nanoparticles (MINPs) on the immune response is vitally important for biomedical applications such as cancer therapy, disease diagnosis and novel cancer imaging. In this study, lipid modified MINPs were… read more here.
Keywords: intracellular accumulation; antigen processing; lipid modified; minps ... See more keywords
Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220782
Abstract: Antigen processing is an immunological mechanism by which intracellular peptides are transported to the cell surface while bound to Major Histocompatibility Complex molecules, where they can be surveyed by circulating CD8+ or CD4+ T-cells, potentially… read more here.
Keywords: structural biology; antigen processing; advancing knowledge; biology ... See more keywords
HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2016.1171447
Abstract: ABSTRACT The human leukocyte antigen (HLA) class II antigen-processing machinery (APM) presents to cognate CD4+ T-cells antigenic peptides mainly generated from exogeneous proteins in the endocytic compartment. These CD4+ T cells exert helper function, but… read more here.
Keywords: class; antigen processing; class antigen; hla class ... See more keywords
The Wiskott-Aldrich syndrome protein regulates antigen processing and presentation by dendritic cells
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12587
Abstract: The Wiskott-Aldrich syndrome protein regulates antigen processing and presentation by dendritic cells read more here.
Keywords: syndrome protein; antigen processing; protein regulates; regulates antigen ... See more keywords
Antigen processing and presentation in cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001111
Abstract: Background Knowledge about and identification of T cell tumor antigens may inform the development of T cell receptor-engineered adoptive cell transfer or personalized cancer vaccine immunotherapy. Here, we review antigen processing and presentation and discuss… read more here.
Keywords: cancer; processing presentation; cell; antigen processing ... See more keywords
Qa-1b Modulates Resistance to Anti–PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0652
Abstract: Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy response are not completely understood. The non-classical MHC class I molecule HLA-E… read more here.
Keywords: immune checkpoint; resistance anti; antigen processing; anti pd1 ... See more keywords