Actinin‐4 controls survival signaling in B cells by limiting the lateral mobility of B‐cell antigen receptors
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350774
Abstract: The structure and dynamics of F‐actin networks in the cortical area of B cells control the signal efficiency of B‐cell antigen receptors (BCRs). Although antigen‐induced signaling has been studied extensively, the role of cortical F‐actin… read more here.
Keywords: antigen; cell; antigen receptors; cortical actin ... See more keywords
Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104222
Abstract: The expansion of polyclonal T regulatory cells (Tregs) offers great promise for the treatment of immune-mediated diseases, such as multiple sclerosis (MS). However, polyclonal Tregs can be non-specifically immunosuppressive. Based on the advancements with chimeric… read more here.
Keywords: cells expressing; regulatory cells; antigen receptors; car ... See more keywords
Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.015
Abstract: Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications… read more here.
Keywords: vector; antigen receptors; cell; car ... See more keywords
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors.
Sign Up to like & getrecommendations! Published in 2025 at "Nature communications"
DOI: 10.1038/s41467-025-66967-3
Abstract: The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α). tmTNF-α can act as either a ligand by activating TNF receptors, or a receptor that… read more here.
Keywords: new antigen; soluble tnf; antigen receptors; tnf alpha ... See more keywords
The characterization of variable new antigen receptors targeting FAP isolated from a novel immunized library
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08610-x
Abstract: Cancer-associated fibroblasts (CAFs) in the stroma of solid tumors promote an immunosuppressive tumor microenvironment (TME) that drives resistance to therapies. The expression of the protease fibroblast activation protein (FAP) on the surface of CAFs has… read more here.
Keywords: new antigen; targeting fap; variable new; antigen receptors ... See more keywords
Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1479
Abstract: Purpose: The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CAR) are typically designed with one or two scFvs that impart… read more here.
Keywords: ankyrin repeat; antigen; tumor; chimeric antigen ... See more keywords
Toward high-throughput engineering techniques for improving CAR intracellular signaling domains
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1101122
Abstract: Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors. The choice and relative positioning of… read more here.
Keywords: intracellular signaling; chimeric antigen; high throughput; antigen receptors ... See more keywords
Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2024.1379900
Abstract: Efficient engineering of T cells to express exogenous tumor-targeting receptors such as chimeric antigen receptors (CARs) or T-cell receptors (TCRs) is a key requirement of effective adoptive cell therapy for cancer. Genome editing technologies, such… read more here.
Keywords: gene editing; chimeric antigen; non viral; antigen receptors ... See more keywords
Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1548630
Abstract: γδ T cells represent a promising cell platform for adoptive cell therapy. Their natural anti-tumor reactivity and HLA-independent target cell recognition make them an attractive platform for allogeneic adoptive immunotherapy clinical interventions. Initial clinical trials… read more here.
Keywords: transduction; vector; chimeric antigen; car ... See more keywords
A brief review concerning Chimeric Antigen Receptors T cell therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.46308
Abstract: The understanding concerning the function of immune system in cancer has achieved considerable advance with time passes by. Manipulating genetically engineered immune cells were investigated as a novel strategy for treating cancer. Chimeric antigen receptors… read more here.
Keywords: cell therapy; antigen receptors; cancer; car ... See more keywords