Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2020.104222
Abstract: The expansion of polyclonal T regulatory cells (Tregs) offers great promise for the treatment of immune-mediated diseases, such as multiple sclerosis (MS). However, polyclonal Tregs can be non-specifically immunosuppressive. Based on the advancements with chimeric… read more here.
Keywords: cells expressing; regulatory cells; antigen receptors; car ... See more keywords
Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.015
Abstract: Antigen-independent tonic signaling by chimeric antigen receptors (CARs) can increase differentiation and exhaustion of T cells, limiting their potency. Incorporating 4-1BB costimulation in CARs may enable T cells to resist this functional exhaustion; however, the potential ramifications… read more here.
Keywords: vector; antigen receptors; cell; car ... See more keywords
Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1479
Abstract: Purpose: The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CAR) are typically designed with one or two scFvs that impart… read more here.
Keywords: ankyrin repeat; antigen; tumor; chimeric antigen ... See more keywords
Toward high-throughput engineering techniques for improving CAR intracellular signaling domains
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1101122
Abstract: Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors. The choice and relative positioning of… read more here.
Keywords: intracellular signaling; chimeric antigen; high throughput; antigen receptors ... See more keywords
A brief review concerning Chimeric Antigen Receptors T cell therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.46308
Abstract: The understanding concerning the function of immune system in cancer has achieved considerable advance with time passes by. Manipulating genetically engineered immune cells were investigated as a novel strategy for treating cancer. Chimeric antigen receptors… read more here.
Keywords: cell therapy; antigen receptors; cancer; car ... See more keywords