The Allosteric Effect in Antibody-Antigen Recognition.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1154-8_11
Abstract: We studied the molecular details of the recognition of antigens by the variable domain of their cognate antibodies in as well as those elicited by the constant domains, which do not directly interact with antigens.… read more here.
Keywords: effect antibody; allosteric effect; antigen recognition; recognition ... See more keywords
Immuno-receptors: from recognition to signaling and function
Sign Up to like & getrecommendations! Published in 2018 at "European Biophysics Journal"
DOI: 10.1007/s00249-018-1294-2
Abstract: The vertebrate adaptive immune response is initiated by specific recognition of antigens. This is carried out by molecules, soluble or cell surface receptors that are members of the Multichain Immune Recognition Receptors (MIRR) group of… read more here.
Keywords: immuno receptors; antigen recognition; recognition; receptors recognition ... See more keywords
P142 Class I variation outside the antigen recognition domain is limited in an argentine registry population
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.202
Abstract: Aim The aim of this study was to use next generation DNA sequencing (NGS) to characterize full length HLA class I gene diversity in 1472 volunteers for the unrelated donor registry in Argentina. Methods DNA… read more here.
Keywords: variation; class; antigen recognition; hla ... See more keywords
Continue to focus clinical decision-making on the antigen recognition domain for the present.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2018.04.010
Abstract: Next generation DNA sequencing has facilitated the routine characterization of complete HLA gene sequences. These data complement structural and functional studies of HLA elements encoded outside of the exons specifying the antigen recognition domain. This… read more here.
Keywords: clinical decision; recognition domain; decision making; antigen recognition ... See more keywords
Therapeutic antibody glycosylation impacts antigen recognition and immunogenicity
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DOI: 10.1111/imm.13481
Abstract: In this study we show that glycosylation is relevant for immune recognition of therapeutic antibodies, and that defined glycan structures can modulate immunogenicity. Concerns regarding immunogenicity arise from the high heterogeneity in glycosylation that is… read more here.
Keywords: recognition; antigen recognition; immunogenicity; antibody glycosylation ... See more keywords
Antigen Recognition Patterns of Intestinal Capillariasis Using Immunoblot-Based Serodiagnosis
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DOI: 10.2478/s11686-020-00233-y
Abstract: Background Diagnosis of intestinal capillariasis depending on microscopic detection of parasitic stages is of low sensitivity, especially in cases with low worm burden. There is a necessity to develop sensitive and specific diagnostic tools of… read more here.
Keywords: recognition patterns; capillariasis using; capillariasis; antigen recognition ... See more keywords
Comparative Pre-Clinical Analysis of CD20-Specific CAR T Cells Encompassing 1F5-, Leu16-, and 2F2-Based Antigen-Recognition Moieties
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043698
Abstract: Over the past decade, CAR T cell therapy for patients with B cell malignancies has evolved from an experimental technique to a clinically feasible option. To date, four CAR T cell products specific for a… read more here.
Keywords: antigen recognition; specific car; based antigen; car ... See more keywords
The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.27311
Abstract: Antibodies are critical components of the human adaptive immune system, providing versatile scaffolds to display diverse antigen-binding surfaces. Nevertheless, most antibodies have similar architectures, with the variable immunoglobulin domains of the heavy and light chain… read more here.
Keywords: antigen binding; antibody; antigen recognition; antigen ... See more keywords