Hollow Aluminum Hydroxide Modified Silica Nanoadjuvants with Amplified Immunotherapy Effects through Immunogenic Cell Death Induction and Antigen Release.
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DOI: 10.1002/smll.202202462
Abstract: In spite of the widespread application of vaccine adjuvants in various preventive vaccines at present, the existing adjuvants are still hindered by weak cellular immunity responses in therapeutic cancer vaccines. Herein, a hollow silica nanoadjuvant… read more here.
Keywords: cell death; aluminum; aluminum hydroxide; immunogenic cell ... See more keywords
Extending antigen release from particulate vaccines results in enhanced antitumor immune response
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DOI: 10.1016/j.jconrel.2017.11.020
Abstract: Abstract Tumor‐specific CD8+ cytotoxic T lymphocytes (CTLs) play a critical role in an anti‐tumor immune response. However, vaccination intended to elicit a potent CD8+ T cell responses employing tumor‐associated peptide antigens, are typically ineffective due… read more here.
Keywords: release; antigen; immune response; antigen release ... See more keywords