An overview of immunoinformatics approaches and databases linking T cell receptor repertoires to their antigen specificity
Sign Up to like & getrecommendations! Published in 2019 at "Immunogenetics"
DOI: 10.1007/s00251-019-01139-4
Abstract: Recent advances in molecular and bioinformatic methods have greatly improved our ability to study the formation of an adaptive immune response towards foreign pathogens, self-antigens, and cancer neoantigens. T cell receptors (TCR) are the key… read more here.
Keywords: antigen specificity; approaches databases; immunoinformatics approaches; overview immunoinformatics ... See more keywords
High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.11.003
Abstract: B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to infection and vaccination, but it provides limited information about the antigen specificity of the sequenced BCRs. Here, we present LIBRA-seq (linking… read more here.
Keywords: cell receptor; antigen specificity; cell; high throughput ... See more keywords
Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm0817-1004a
Abstract: Nat. Med. 22, 1482–1487 (2016); published online 31 October 2016; corrected after print 18 April 2017 In the version of this article initially published, the IA-2545–562 peptide identified as a target of a T cell… read more here.
Keywords: antigen specificity; specificity islet; islet infiltrating; self antigen ... See more keywords
Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01701
Abstract: CD4+Foxp3+ T regulatory cells (Treg) are essential for the life of the organism, in particular because they protect the host against its own autoaggressive CD4+Foxp3− T lymphocytes (Tconv). Treg distinctively suppress autoaggressive immunity while permitting… read more here.
Keywords: antigen specificity; immunopathology; cd4 foxp3; treg ... See more keywords
Antigen-specificity measurements are the key to understanding T cell responses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1127470
Abstract: Antigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing… read more here.
Keywords: specificity measurements; specific cells; antigen specific; antigen specificity ... See more keywords
Corrigendum: Predicting T Cell Receptor Antigen Specificity From Structural Features Derived From Homology Models of Receptor-Peptide-Major Histocompatibility Complexes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.790998
Abstract: [This corrects the article DOI: 10.3389/fphys.2021.730908.]. read more here.
Keywords: specificity structural; predicting cell; antigen specificity; receptor antigen ... See more keywords