Antigenic drift originating from changes to the lateral surface of the neuraminidase head of influenza A virus
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DOI: 10.1038/s41564-019-0401-1
Abstract: Influenza viruses possess two surface glycoproteins, haemagglutinin and neuraminidase (NA). Although haemagglutinin plays a major role as a protective antigen, immunity to NA also contributes to protection. The NA protein consists of a stalk and… read more here.
Keywords: head; lateral surface; surface; activity ... See more keywords
Antigenic Drift Defines a New D4 Subgenotype of Measles Virus
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DOI: 10.1128/jvi.00209-17
Abstract: ABSTRACT The measles virus hemagglutinin (MeV-H) protein is the main target of protective neutralizing antibodies. Using a panel of monoclonal antibodies (MAbs) that recognize known major antigenic sites in MeV-H, we identified a D4 genotype… read more here.
Keywords: mev; virus antigenic; drift defines; neutralization ... See more keywords
Evolution and Antigenic Advancement of N2 Neuraminidase of Swine Influenza A Viruses Circulating in the United States following Two Separate Introductions from Human Seasonal Viruses
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DOI: 10.1128/jvi.00632-21
Abstract: Antibodies inhibiting the neuraminidase (NA) of IAV reduce clinical disease, virus shedding, and transmission, particularly in the absence of neutralizing immunity against hemagglutinin. To understand antibody recognition of the genetically diverse NA in U.S. swine… read more here.
Keywords: antigenic drift; human seasonal; iav; swine ... See more keywords
Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses
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DOI: 10.3390/v12020248
Abstract: The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains. However, as surveillance activities on swIAV have increased, more… read more here.
Keywords: swine influenza; drift; influenza viruses; swine ... See more keywords
Modeling Infectious Bursal Disease Virus (IBDV) Antigenic Drift In Vitro
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DOI: 10.3390/v15010130
Abstract: Infectious bursal disease virus (IBDV) vaccines do not induce sterilizing immunity, and vaccinated birds can become infected with field strains. Vaccine-induced immune selection pressure drives the evolution of antigenic drift variants that accumulate amino acid… read more here.
Keywords: bursal disease; ibdv; antigenic drift; virus ... See more keywords