Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance
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DOI: 10.1172/jci122895
Abstract: Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies. Here, a panel of mutant viruses each… read more here.
Keywords: immunodominance; antigenic sites; species specific; hemagglutinin ... See more keywords
Potential of conserved antigenic sites in development of universal SARS-like coronavirus vaccines
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DOI: 10.3389/fimmu.2022.952650
Abstract: Given pandemic risks of zoonotic SARS-CoV-2 variants and other SARS-like coronaviruses in the future, it is valuable to perform studies on conserved antigenic sites to design universal SARS-like coronavirus vaccines. By using antibodies obtained from… read more here.
Keywords: like coronavirus; sars like; conserved antigenic; universal sars ... See more keywords
Mapping of foot-and-mouth disease virus antigenic sites recognized by single-domain antibodies reveals different 146S particle specific sites and particle flexibility
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DOI: 10.3389/fvets.2022.1040802
Abstract: Vaccination with intact (146S) foot-and-mouth disease virus (FMDV) particles is used to control FMD. However, 146S particles easily dissociate into stable pentameric 12S particles which are less immunogenic. We earlier isolated several single-domain antibody fragments… read more here.
Keywords: foot mouth; 146s specific; mouth disease; antigenic sites ... See more keywords