Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.117
Abstract: The Lyme disease spirochete, Borrelia burgdorferi, uses antigenic variation as a strategy to evade the host's acquired immune response. New variants of surface-localized VlsE are generated efficiently by unidirectional recombination from 15 unexpressed vls cassettes… read more here.
Keywords: prone repair; variation; antigenic variation; recombinational switching ... See more keywords
Correlation between antigenicity and variability in the vls antigenic variation system of Borrelia burgdorferi.
Sign Up to like & getrecommendations! Published in 2017 at "Microbes and infection"
DOI: 10.1016/j.micinf.2017.01.001
Abstract: Many parasites have evolved antigenic variation systems that alter surface proteins in order to evade recognition by presently expressed antibodies and subsequent death. Although the amino acid positions in antigens to which antibodies most commonly… read more here.
Keywords: variation system; amino acid; antigenic variation; vls antigenic ... See more keywords
Genome organization and DNA accessibility control antigenic variation in trypanosomes
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0619-8
Abstract: Many evolutionarily distant pathogenic organisms have evolved similar survival strategies to evade the immune responses of their hosts. These include antigenic variation, through which an infecting organism prevents clearance by periodically altering the identity of… read more here.
Keywords: genome architecture; gene; variation; antigenic variation ... See more keywords
Antigenic variation of SARS‐CoV‐2 in response to immune pressure
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Ecology"
DOI: 10.1111/mec.15730
Abstract: Analysis of the bat viruses most closely related to SARS‐CoV‐2 indicated that the virus probably required limited adaptation to spread in humans. Nonetheless, since its introduction in human populations, SARS‐CoV‐2 must have been subject to… read more here.
Keywords: cov response; antigenic variation; variation sars; sars cov ... See more keywords
Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.13873
Abstract: The Lyme disease spirochete evades the host immune system by combinatorial variation of VlsE, a surface antigen. Antigenic variation occurs via segmental gene conversion from contiguous silent cassettes into the vlsE locus. Because of the… read more here.
Keywords: pacbio sequencing; variation; antigenic variation; pipeline ... See more keywords
Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Microbiology"
DOI: 10.1111/mmi.14189
Abstract: Borrelia burgdorferi is a causative agent of Lyme disease and establishes long‐term infection in mammalian hosts. Persistence is promoted by the VlsE antigenic variation system, which generates combinatorial diversity of VlsE through unidirectional, segmental gene… read more here.
Keywords: switching vlse; antigenic variation; recombinational switching; jd1 ... See more keywords
Mechanisms of Surface Antigenic Variation in the Human Pathogenic Fungus Pneumocystis jirovecii
Sign Up to like & getrecommendations! Published in 2017 at "mBio"
DOI: 10.1128/mbio.01470-17
Abstract: ABSTRACT Microbial pathogens commonly escape the human immune system by varying surface proteins. We investigated the mechanisms used for that purpose by Pneumocystis jirovecii. This uncultivable fungus is an obligate pulmonary pathogen that in immunocompromised… read more here.
Keywords: antigenic variation; surface; family; gene ... See more keywords
PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2019 at "mSphere"
DOI: 10.1128/msphere.00562-19
Abstract: Diversity generation systems are used by many unicellular organism to provide subpopulations of cell with different properties that are available when needed. We have developed a method using the PacBio DNA sequencing technology and a… read more here.
Keywords: variation; neisseria gonorrhoeae; variation frequencies; antigenic variation ... See more keywords
O01.2 Genetic, structural, and surface antigenic variation of treponema pallidum’s OMPeome: steps towards a global syphilis vaccine
Sign Up to like & getrecommendations! Published in 2019 at "Sexually Transmitted Infections"
DOI: 10.1136/sextrans-2019-sti.105
Abstract: Background The failure of current prevention strategies to curtail the spread of syphilis, including mother-to-child transmission, underscores the need for a vaccine with worldwide efficacy. Characterization of variation within T. pallidum (TPA) outer membrane proteins… read more here.
Keywords: surface antigenic; variation; antigenic variation; tpa ... See more keywords
Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.852239
Abstract: Cellular decision-making at the level of gene expression is a key process in the development and evolution of every organism. Variations in gene expression can lead to phenotypic diversity and the development of subpopulations with… read more here.
Keywords: antigenic variation; expression; gene expression; mutually exclusive ... See more keywords
Nuclear Condensates: New Targets to Combat Parasite Immune Evasion?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.942200
Abstract: Antigenic variation is a successful strategy employed by numerous pathogens to evade the host immune system. It describes the frequent exchange of antigens, which prevents detection and elimination by the host immune system. Strikingly, pathogens… read more here.
Keywords: nuclear condensates; antigenic variation; transcription; variation ... See more keywords