PTML modeling for peptide discovery: in silico design of non-hemolytic peptides with antihypertensive activity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular diversity"
DOI: 10.1007/s11030-021-10350-z
Abstract: Hypertension is a medical condition that affects millions of people worldwide. Despite the high efficacy of the current antihypertensive drugs, they are associated with serious side effects. Peptides constitute attractive options for chemical therapy against… read more here.
Keywords: silico; ptml mlp; ptml modeling; antihypertensive activity ... See more keywords
Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112039
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Parsley (Petroselinum crispum; P. crispum) is among the popular aromatic vegetables and a part of the daily diet in the Mediterranean area. This plant is widely used in alternative medicine as a remedy… read more here.
Keywords: calcium channels; antihypertensive activity; petroselinum crispum; crispum ... See more keywords
Enhanced bioavailability and antihypertensive activity of nisoldipine loaded nanoemulsion: optimization, cytotoxicity and uptake across Caco-2 cell line, pharmacokinetic and pharmacodynamic studies
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1724128
Abstract: Abstract Objective: The present study explored the antihypertensive activity of nisoldipine in oil in water nanoemulsion to improve its oral bioavailability via intestinal lymphatic uptake. Methods: Nanoemulsion was prepared by ultrasonication technique using Peceol, Cremophor… read more here.
Keywords: bioavailability; drug; nanoemulsion; antihypertensive activity ... See more keywords
Antihypertensive activity of fish protein hydrolysates and its peptides
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Food Science and Nutrition"
DOI: 10.1080/10408398.2018.1452182
Abstract: ABSTRACT The rising interest to utilize nutritionally exorbitant fish proteins has instigated research activities in fish waste utilization. The development of newer technologies to utilize fish waste has fostered use of bioactive value-added products for… read more here.
Keywords: activity fish; protein hydrolysates; antihypertensive activity; activity ... See more keywords
PAAP: a web server for predicting antihypertensive activity of peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2017-0300
Abstract: AIM Hypertension is associated with development of cardiovascular disease and has become a significant health problem worldwide. Naturally-derived antihypertensive peptides have emerged as promising alternatives to synthetic drugs. MATERIALS & METHODS This study introduces predictor… read more here.
Keywords: activity peptides; paap web; web server; server predicting ... See more keywords