Rational Design of a Highly Specific Prolyl Endopeptidase To Activate the Antihypertensive Effect of Peptides
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200691
Abstract: Enzymatic hydrolysis of food‐derived proteins to produce bioactive peptides could activate food functions such as antihypertension. However, the diversity of enzymatic hydrolysis products can reduce bioactive peptides’ efficacy. Highly specific proteases can homogenize the hydrolysis… read more here.
Keywords: prolyl endopeptidase; bioactive peptides; highly specific; antihypertensive effect ... See more keywords
Short- and long-term antihypertensive effect of egg protein-derived peptide QIGLF.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.7762
Abstract: BACKGROUND The present study aimed to investigate the in vivo antihypertensive effect on spontaneously hypertensive rats (SHRs) induced by egg protein-derived peptide QIGLF, which has been previously characterized in vitro as a potent angiotensin-converting enzyme… read more here.
Keywords: protein derived; peptide qiglf; antihypertensive effect; effect ... See more keywords
Frequency-dependent depression of the NTS synapse affects the temporal response of the antihypertensive effect of auricular vagus nerve stimulation (aVNS)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac857a
Abstract: Objective. Auricular vagus nerve stimulation (aVNS) has recently emerged as a promising neuromodulation modality for blood pressure (BP) reduction due to its ease of use although its efficacy is still limited compared to direct baroreflex… read more here.
Keywords: frequency; depression; antihypertensive effect; avns ... See more keywords
[BP.02.04] THE ANTIHYPERTENSIVE EFFECT OF EMPAGLIFLOZIN IN RATS WITH NON-DIABETIC NEPHROSIS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523474.10115.d6
Abstract: Objective: The effects of sodium-glucose cotransporter-2 (SGLT2) inhibiton on lowering blood pressure are well characterized in diabetic animals and humans. However, it is unclear whether SGLT2 inhibitors may have antihypertensive effects in non-diabetic kidney disease.… read more here.
Keywords: antihypertensive effect; empagliflozin; hypertension; day ... See more keywords
Antihypertensive effect of carvacrol is improved after incorporation in β‐cyclodextrin as a drug delivery system
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13364
Abstract: Carvacrol (CARV), has been shown to possess various pharmacological properties, especially in the treatment of cardiovascular diseases. We evaluated the antihypertensive effect of the CARV free and encapsulation of CARV in β‐cyclodextrin (CARV/β‐CD), and whether… read more here.
Keywords: carv; antihypertensive effect; effect carvacrol; group ... See more keywords
Chronic Limb Remote Ischemic Conditioning may have an Antihypertensive Effect in Patients with Hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Aging and Disease"
DOI: 10.14336/ad.2021.0604
Abstract: Hypertension is the leading preventable risk factor for all-cause morbidity and mortality worldwide. Despite antihypertensive medications have been available for decades, a big challenge we are facing is to increase the blood pressure (BP) control… read more here.
Keywords: limb remote; ischemic conditioning; hypertension; remote ischemic ... See more keywords
Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1110459
Abstract: Chronopharmacology of arterial hypertension impacts the long-term cardiovascular risk of hypertensive subjects. Therefore, clinical and computational studies have proposed optimizing antihypertensive medications’ dosing time (Ta). However, the causes and mechanisms underlying the Ta-dependency antihypertensive effect… read more here.
Keywords: dosing time; valsartan aspirin; effect; antihypertensive effect ... See more keywords
Antihypertensive Effect of Amaranth Hydrolysate Is Comparable to the Effect of Low-Intensity Physical Activity
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DOI: 10.3390/app10165706
Abstract: Background and objectives: Both antihypertensive peptide intake and physical activity help to control blood pressure. Our aim was to evaluate the impact of consuming amaranth antihypertensive peptides on systolic blood pressure (SBP) in normotensive rats… read more here.
Keywords: antihypertensive effect; eight weeks; supplemented eight; effect ... See more keywords
Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide
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DOI: 10.3390/biom10070992
Abstract: The peptide AVFQHNCQE demonstrated to produce nitric oxide-mediated antihypertensive effect. This study investigates the bioavailability and the opioid-like activity of this peptide after its oral administration. For this purpose, in silico and in vitro approaches… read more here.
Keywords: antihypertensive effect; effect; opioid receptors; implication opioid ... See more keywords
In Vitro and In Vivo Antihypertensive Effect of Milk Fermented with Different Strains of Common Starter Lactic Acid Bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14245357
Abstract: Currently, functional dairy products pave a promising way for the prophylaxis of essential hypertension, and the search for new strains capable of producing such products is a constant challenge for scientists around the world. In… read more here.
Keywords: vitro vivo; vivo antihypertensive; antihypertensive effect; milk ... See more keywords