Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties.
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DOI: 10.1021/acs.jmedchem.7b01557
Abstract: Excessive NF-κB activation contributes to the pathogenesis of numerous diseases. Small-molecule inhibitors of NF-κB signaling have significant therapeutic potential especially in treating inflammatory diseases and cancers. In this study, we performed a cell-based high-throughput screening… read more here.
Keywords: antiinflammatory anticancer; inhibitors signaling; small molecule; molecule inhibitors ... See more keywords
Antiinflammatory and Anticancer Properties of Grewia asiatica Crude Extracts and Fractions: A Bioassay-Guided Approach
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DOI: 10.1155/2022/2277417
Abstract: The study was an extension of our earlier work on antiinflammatory and anticancer properties of G. asiatica fruit. We aimed to develop a bioassay guided multistep purification technique for producing bioactive fractions of G. asiatica… read more here.
Keywords: crude extracts; anticancer properties; asiatica crude; bioassay guided ... See more keywords