Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113101
Abstract: The kinetoplastid parasites Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. are the causative agents of neglected tropical diseases with a serious burden in several parts of the world. These parasites are incapable of synthesizing purines… read more here.
Keywords: collection purine; antikinetoplastid agents; evaluation collection; synthesis evaluation ... See more keywords
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113290
Abstract: Kinetoplastid parasites are the causative agents of neglected tropical diseases with an unmet medical need. These parasites are unable to synthesize the purine ring de novo, and therefore rely on purine salvage to meet their… read more here.
Keywords: antikinetoplastid agents; deazapurine nucleosides; evaluation fluorinated; fluorinated deazapurine ... See more keywords