A recent update on new synthetic chiral compounds with antileishmanial activity
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23494
Abstract: Abstract Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current… read more here.
Keywords: chiral compounds; new synthetic; activity; update new ... See more keywords
Novel &bgr;‐carboline‐quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.12.012
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Visceral Leishmaniasis is a deadly parasitic disease caused by Leishmania donovani. Paucity exists in the discovery of novel chemotherapeutics against Leishmaniasis. In this study, we synthesized a natural… read more here.
Keywords: bgr carboline; carboline quinazolinone; donovani; activity ... See more keywords
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2017.01.002
Abstract: The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal health. Several bioactivities have been described in extracts from… read more here.
Keywords: cystoseira; cystoseira baccata; activity meroditerpenoids; compound ... See more keywords
Potent in vitro antileishmanial activity of a nanoformulation of cisplatin with carbon nanotubes against Leishmania major.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.09.004
Abstract: OBJECTIVES The aim of this study was to evaluate the cytotoxicity and antileishmanial activity of cisplatin-bonded carbon nanotubes both against promastigotes and amastigotes of Leishmania major in vitro. METHODS Cisplatin-bonded single-walled carbon nanotubes (CP-SWCNT) and… read more here.
Keywords: glucantime; cisplatin; carbon nanotubes; antileishmanial activity ... See more keywords
O-alkyl hydroxamates display potent and selective antileishmanial activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b02016
Abstract: Leishmania (L.) infantum causes visceral, cutaneous and mucosal leishmaniasis in humans and canine leishmaniasis in dogs. Herein, we describe that O-alkyl hydroxamate derivatives displayed potent and selective in vitro activity against the amastigote stage of… read more here.
Keywords: potent selective; alkyl hydroxamates; hydroxamates display; activity ... See more keywords
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.
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DOI: 10.1039/c7md00008a
Abstract: A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most… read more here.
Keywords: antitrypanosomal antileishmanial; prenyl triazoles; activity prenyl; prenyl ... See more keywords
Curvulin and spirostaphylotrichins R and U from extracts produced by two endophytic Bipolaris sp. associated to aquatic macrophytes with antileishmanial activity
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1380011
Abstract: Abstract In the present study, biological activity and chemical composition of two crude extracts of endophytic fungal strains of Bipolaris genera isolated from two species of aquatic macrophytes: Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.)… read more here.
Keywords: curvulin spirostaphylotrichins; aquatic macrophytes; spirostaphylotrichins extracts; activity ... See more keywords
Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007227
Abstract: Background There is a pressing need for drug discovery against visceral leishmaniasis, a life-threatening protozoal infection, as the available chemotherapy is antiquated and not bereft of side effects. Plants as alternate drug resources has rewarded… read more here.
Keywords: production; cbd; cassia; cinnamomum cassia ... See more keywords
Synthesis, antileishmanial activity and QSAR studies of 2-chloro- N -arylacetamides
Sign Up to like & getrecommendations! Published in 2017 at "Brazilian Journal of Pharmaceutical Sciences"
DOI: 10.1590/s2175-97902017000116067
Abstract: We describe herein the synthesis and evaluation of the antileishmanial activity against promastigote forms of Leishmania amazonensis and cytotoxicity to murine macrophages of a series of 2-chloro-N-arylacetamide derivatives. All compounds were active, except one (compound… read more here.
Keywords: synthesis antileishmanial; activity qsar; qsar studies; activity ... See more keywords
Synthesis and in vitro antileishmanial activity of alkylene-linked nitrofurantoin-triazole hybrids.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4261625
Abstract: Leishmaniasis is a vector-borne parasitic disease that mostly affects populations in tropical and sub-tropical countries. There is currently no protective anti-leishmanial vaccine and only a paucity of clinical drugs is available to treat this disease… read more here.
Keywords: activity alkylene; synthesis vitro; alkylene; vitro antileishmanial ... See more keywords
Synthesis and Evaluation of the Antileishmanial Activity of Novel Eugenol Analogs Containing 1,2,3-Triazole Fragments Against Intracellular Leishmania braziliensis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20230073
Abstract: This investigation describes the synthesis of eugenol analogs presenting 1,2,3-triazole fragments and evaluation of their antileishmanial activity. The alkylation of guaiacol (1) with allyl bromide afforded 1-(allyloxy)-2-methoxybenzene (2) (93% yield). The Claisen rearrangement conducted with… read more here.
Keywords: braziliensis; evaluation antileishmanial; triazole fragments; eugenol analogs ... See more keywords