Articles with "antileishmanial agents" as a keyword



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Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents

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Published in 2021 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.1c00813

Abstract: Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a… read more here.

Keywords: heteroarylquinolines potential; substituted aryl; potential antileishmanial; aryl heteroarylquinolines ... See more keywords
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Pyrimido[5,4-d]pyrimidine-Based Compounds as a Novel Class of Antitrypanosomal and Antileishmanial Agents.

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Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00170

Abstract: Sleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions of people. The currently available therapies present several limitations, including high toxicity, lack of efficacy, and emerging drug resistance, prompting a search for novel… read more here.

Keywords: antitrypanosomal antileishmanial; antileishmanial agents; pyrimido pyrimidine; novel class ... See more keywords