Synthesis and in vitro antileishmanial efficacy of novel benzothiadiazine‐1,1‐dioxide derivatives
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DOI: 10.1002/ardp.202000280
Abstract: Leishmaniasis is a major vector‐borne parasitic disease that affects thousands of people in tropical and subtropical developing countries. In 2019 alone, it killed 26,000–65,000 individuals. Leishmaniasis is curable, yet its eradication and elimination are hampered… read more here.
Keywords: vitro antileishmanial; antileishmanial efficacy; efficacy novel; synthesis vitro ... See more keywords
Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200023
Abstract: Leishmaniasis is a vector‐borne neglected parasitic infection affecting thousands of individuals, mostly among populations in low‐ to moderate‐income developing countries. In the absence of protective vaccines, the management of the disease banks solely on chemotherapy.… read more here.
Keywords: nitrofurantoin triazole; synthesis vitro; efficacy hit; vitro antileishmanial ... See more keywords
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide
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DOI: 10.1002/ddr.21755
Abstract: Leishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat this disease.… read more here.
Keywords: vitro antileishmanial; synthesis vitro; benzyl analogues; antileishmanial efficacy ... See more keywords
Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s196421
Abstract: Background Amphotericin B (AmB) as a liposomal formulation of AmBisome is the first line of treatment for the disease, visceral leishmaniasis, caused by the parasite Leishmania donovani. However, nephrotoxicity is very common due to poor… read more here.
Keywords: antileishmanial efficacy; covalent; covalent conjugate; amb ... See more keywords