An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
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DOI: 10.1016/j.ejmech.2017.04.044
Abstract: The azole antifungal drugs are an important class of chemotherapeutic agents with broad-spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic pathway through inhibition of the cytochrome P450-dependent enzyme sterol 14α-demethylase.… read more here.
Keywords: sterol demethylase; antileishmanial therapy; sterol; chemistry ... See more keywords