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Antileukemic effects of midostaurin in acute myeloid leukemia – the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells

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Published in 2017 at "Expert Opinion on Investigational Drugs"

DOI: 10.1080/13543784.2017.1275564

Abstract: ABSTRACT Introduction: Midostaurin is a multikinase inhibitor that inhibits receptor tyrosine kinases (Flt3, CD117/c-kit, platelet-derived growth factor receptor, vascular endothelial growth factor receptor 2) as well as non-receptor tyrosine kinases (Frg, Src, Syk, Protein kinase… read more here.

Keywords: antileukemic effects; myeloid leukemia; stromal cells; inhibition ... See more keywords