Effects of lipophilicity, protecting group and stereochemistry on the antimalarial activity of carbohydrate-derived thiochromans
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2105-5
Abstract: A series of novel carbohydrate-derived thiochromans has been successfully synthesized in order to investigate the influence of alkyl substituents on the aromatic ring of the thiophenol moiety in addition to the effect of protecting groups… read more here.
Keywords: carbohydrate derived; protecting group; antimalarial activity; derived thiochromans ... See more keywords
Enhancing the antimalarial activity of artesunate
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06786-1
Abstract: The global challenge to the treatment of malaria is mainly the occurrence of resistance of malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic artemisinin compound, and other artemisinin derivatives are currently used in combination… read more here.
Keywords: enhancing antimalarial; antimalarial activity; resistance; artemisinin ... See more keywords
Synthesis, antimalarial activity, heme binding and docking studies of N-substituted 4-aminoquinoline-pyrimidine molecular hybrids.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.024
Abstract: A series of novel N-substituted 4-aminoquinoline-pyrimidine hybrids have been synthesized via simple and economic route and evaluated for their antimalarial activity. Most compounds showed potent antimalarial activity against both CQ-sensitive and CQ-resistant strains with high… read more here.
Keywords: substituted aminoquinoline; aminoquinoline pyrimidine; antimalarial activity; activity ... See more keywords
N-Substituted aminoquinoline-pyrimidine hybrids: Synthesis, in vitro antimalarial activity evaluation and docking studies.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.021
Abstract: A series of novel molecular hybrids based on 4-aminoquinoline-pyrimidine were synthesized and examined for their antimalarial activity. Most of the compounds were found to have potent in vitro antimalarial activity against both CQ-sensitive D6 and CQ-resistant… read more here.
Keywords: vitro antimalarial; docking studies; aminoquinoline pyrimidine; antimalarial activity ... See more keywords
Synthesis and antimalarial activity of 3′-trifluoromethylated 1,2,4-trioxolanes and 1,2,4,5-tetraoxane based on deoxycholic acid
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2017.11.008
Abstract: HIGHLIGHTSDeoxycholic acid ozonides were synthesized via the Griesbaum coozonolysis for the first time.Two novel steroidal tetraoxanes were obtained by acid‐catalyzed peroxycondensation.Antimalarial activity was evaluated and potency for related compounds was compared. ABSTRACT A series of… read more here.
Keywords: methyl; deoxycholic acid; antimalarial activity; trifluoromethylated trioxolanes ... See more keywords
Reduction of the Double Bond of 6-Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c05041
Abstract: Novel 6-arylethyl-1,2,4-trioxanes6a–i and 7a–i are easily accessible in one step from the diimide reduction of 6-arylvinyl-1,2,4-trioxanes 5a–i. All of these new trioxanes were assessed for their oral antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in… read more here.
Keywords: protection; arylvinyl trioxanes; antimalarial activity; dose days ... See more keywords
Total synthesis and antimalarial activity of mortiamides A-D.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02864a
Abstract: Mortiamides A-D (1-4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A-D (1-4) on… read more here.
Keywords: synthesis antimalarial; activity mortiamides; total synthesis; antimalarial activity ... See more keywords
In‐vitro and in‐vivo antimalarial activity of caffeic acid and some of its derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12982
Abstract: To explore the in‐vitro and in‐vivo antimalarial potential of caffeic acid and derivatives. read more here.
Keywords: caffeic acid; vitro vivo; antimalarial activity; acid derivatives ... See more keywords
Thiazole Containing Heterocycles with Antimalarial Activity.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug discovery technologies"
DOI: 10.2174/1570163814666170725114159
Abstract: BACKGROUND Heterocyclic compounds are the main class of medicinally important compounds. Many heterocyclic compounds bearing a five-membered ring in their structure have a good spectrum of biological activities. Thiazole is an important class of five-membered… read more here.
Keywords: thiazole; heterocyclic compounds; drug; antimalarial activity ... See more keywords
Antimalarial Activity of Lamiaceae Family Plants: Review
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DOI: 10.31838/srp.2020.7.51
Abstract: Malaria is a major infectious disease caused by Plasmodium sp., and it can infect humans trough females mosquitos Anopheles sp. bite. Plasmodium resistance to malarial drugs used today occurs mostly in endemic areas, so it… read more here.
Keywords: family plants; antimalarial activity; active antimalarial; lamiaceae family ... See more keywords
Antimalarial Activity of Plant Metabolites
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051382
Abstract: Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria.… read more here.
Keywords: plant; plant metabolites; antimalarial activity; review ... See more keywords