Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discovery
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4148
Abstract: Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and P. vivax (Pv) are responsible for causing… read more here.
Keywords: structural analyses; antimalarial drug; drug; trna synthetases ... See more keywords
Adaptation and optimization of a fluorescence-based assay for in vivo antimalarial drug screening
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology Research"
DOI: 10.1007/s00436-017-5477-z
Abstract: The in vivo efficacy of potential antimalarials is usually evaluated by direct microscopic determination of the parasitaemia of Plasmodium-infected mice on Giemsa-stained blood smears. This process is time-consuming, requires experienced technicians and is not automatable.… read more here.
Keywords: fluorescence; fluorescence based; antimalarial drug; based assay ... See more keywords
Antimalarial drug artesunate is effective against chemoresistant anaplastic thyroid carcinoma via targeting mitochondrial metabolism
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-020-09824-w
Abstract: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid malignancies and resistant to chemotherapy. Novel therapeutic strategy is required for better management of ATC. In this work, we show that artesunate, an antimalarial… read more here.
Keywords: anaplastic thyroid; antimalarial drug; thyroid carcinoma; atc cells ... See more keywords
Change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and susceptibility to antimalarial drug: Possible role of epigenetic phenomenon
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2016.12.006
Abstract: Abstract Malaria is an important tropical mosquito borne infection. It is still the present global public health issue. The management of malaria requires antimalarial drugs. The resistance to antimalarial drugs is a very big problem.… read more here.
Keywords: pfatp6; change; antimalarial drug; susceptibility antimalarial ... See more keywords
Quantification of the antimalarial drug pyronaridine in whole blood using LC–MS/MS — Increased sensitivity resulting from reduced non-specific binding
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.08.023
Abstract: HIGHLIGHTSSensitive and accurate method suitable for high‐throughput routine analysis of pyronaridine in whole blood.Validated according to US FDA bioanalytical validation guidelines.Described impact on freeze and thaw stability using different anticoagulants.Described adsorption and carry‐over issues and… read more here.
Keywords: drug; whole blood; antimalarial drug; pyronaridine whole ... See more keywords
An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra04867j
Abstract: Tafenoquine (TQ), a fluorescent antimalarial drug, was used as a receptor for the fluorometric detection of hypochlorite (OCl−). TQ itself exhibits a strong fluorescence at 476 nm, but OCl−-selective cyclization of its pentan-1,4-diamine moiety creates… read more here.
Keywords: detection; tafenoquine fluorescent; antimalarial drug; detection hypochlorite ... See more keywords
A sustainable, efficient, and potentially cost-effective approach to the antimalarial drug candidate MMV688533
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc01699d
Abstract: A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. read more here.
Keywords: candidate mmv688533; antimalarial drug; drug candidate;
Tutankhamun’s Antimalarial Drug for Covid-19
Sign Up to like & getrecommendations! Published in 2020 at "Drug Research"
DOI: 10.1055/a-1274-1264
Abstract: Drug repositioning is a strategy that identifies new uses of approved drugs to treat conditions different from their original purpose. Current efforts to treat Covid-19 are based on this strategy. The first drugs used in… read more here.
Keywords: antimalarial drug; drug; covid; tutankhamun antimalarial ... See more keywords
The genomic architecture of antimalarial drug resistance
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elz008
Abstract: Abstract Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to nearly all known antimalarials. The ability of malaria parasites to develop… read more here.
Keywords: genomic architecture; drug resistance; antimalarial drug; resistance ... See more keywords
Antimalarial Drug Resistance: A Threat to Malaria Elimination.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a025619
Abstract: Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins… read more here.
Keywords: drug resistance; antimalarial drug; drug; artemisinin resistance ... See more keywords
A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13476
Abstract: GSK3191607, a novel inhibitor of the Plasmodium falciparum ATP4 (PfATP4) pathway, is being considered for development in humans. However, a key problem encountered during the preclinical evaluation of the compound was its inconsistent pharmacokinetic (PK)… read more here.
Keywords: gsk3191607; drug gsk3191607; study antimalarial; human microdose ... See more keywords