Covalent inhibition of P. falciparum ferredoxin-NADP+ reductase: Exploring alternative strategies for the development of new antimalarial drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.008
Abstract: The protozoan Plasmodium falciparum is the main aetiological agent of tropical malaria. Characteristic of the phylum is the presence of a plastid-like organelle which hosts several homologs of plant proteins, including a ferredoxin (PfFd) and… read more here.
Keywords: ferredoxin; reductase; covalent inhibition; falciparum ... See more keywords
SnapShot: Antimalarial Drugs
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.006
Abstract: Malaria is a prominent vector-borne illness caused by Plasmodium parasites. Therapeutic intervention remains a critical component for disease eradication efforts but is complicated by the emergence of drug resistance. This SnapShot summarizes the human-relevant stages… read more here.
Keywords: snapshot antimalarial; antimalarial drugs;
The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.09.012
Abstract: Assays used to evaluate the transmission-blocking activity of antimalarial drugs are largely focused on their potential to inhibit or reduce the infectivity of gametocytes, the blood stages of the parasite that are responsible for the… read more here.
Keywords: transmission; artesunate sulfadoxine; sulfadoxine pyrimethamine; blood ... See more keywords
Not ordinary antimalarial drugs: Madagascar plant decoctions potentiating the chloroquine action against Plasmodium parasites
Sign Up to like & getrecommendations! Published in 2017 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2017.03.032
Abstract: Abstract Malaria mortality rates have fallen by 47% globally since 2000 and by 54% in the African region, but they are still a major problem. Malaria is caused by Plasmodium parasites, vectored to people through… read more here.
Keywords: plant; plasmodium parasites; resistance; plasmodium ... See more keywords
The in-vivo Mode of Action of Quinoline Antimalarial Drugs Unveiled by X-ray Microscopy
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620023508
Abstract: Emerging resistance of malaria-causing parasites Plasmodium to current drug treatments highlights the need for identifying efficient targets to improve antimalarial therapies. Malaria symptoms appear when Plasmodium parasites are released into the blood stream where they… read more here.
Keywords: antimalarial drugs; microscopy; vivo mode; action quinoline ... See more keywords
Metalloaminopeptidases of the Protozoan Parasite Plasmodium falciparum as Targets for the Discovery of Novel Antimalarial Drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01721
Abstract: Malaria poses a significant threat to approximately half of the world's population with an annual death toll close to half a million. The emergence of resistance to front-line antimalarials in the most lethal human parasite… read more here.
Keywords: novel antimalarial; plasmodium falciparum; metalloaminopeptidases protozoan; protozoan parasite ... See more keywords
A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.5b00141
Abstract: Mutational changes in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) have been associated with differential responses to a wide spectrum of biologically active compounds including current and former quinoline and quinoline-like antimalarial drugs. PfCRT confers… read more here.
Keywords: pfcrt; plasmodium falciparum; falciparum strains; responsiveness quinoline ... See more keywords
Tutankhamun’s Antimalarial Drug for Covid-19
Sign Up to like & getrecommendations! Published in 2020 at "Drug Research"
DOI: 10.1055/a-1274-1264
Abstract: Drug repositioning is a strategy that identifies new uses of approved drugs to treat conditions different from their original purpose. Current efforts to treat Covid-19 are based on this strategy. The first drugs used in… read more here.
Keywords: antimalarial drug; drug; covid; tutankhamun antimalarial ... See more keywords
Antimalarial drugs: what’s new in the patents?
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2203814
Abstract: ABSTRACT Introduction The efficacy of current therapeutic warheads in preventing malaria transmission or treating the disease is often hampered by the emergence of drug-resistance. No effective vaccines are available to date, and novel drugs able… read more here.
Keywords: patents antimalarial; new patents; antimalarial drugs; drugs new ... See more keywords
A proteomic glimpse into the effect of antimalarial drugs on Plasmodium falciparum proteome towards highlighting possible therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Pathogens and disease"
DOI: 10.1093/femspd/ftaa071
Abstract: There is no effective vaccine against malaria; therefore, chemotherapy is to date the only choice to fight against this infectious disease. However, there is growing evidences of drug-resistance mechanisms in malaria treatments. Therefore, the identification… read more here.
Keywords: drug targets; falciparum proteome; antimalarial drugs; drugs plasmodium ... See more keywords
Association of antimalarial drugs with decreased overall and cause specific mortality in systemic lupus erythematosus.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa485
Abstract: OBJECTIVE To evaluate the association and dose-response pattern between antimalarial drugs and overall and cause specific mortality in SLE patients. METHODS Medical records including information on HCQ/chloroquine (CQ) prescription were extracted from Jiangsu Lupus database.… read more here.
Keywords: overall cause; mortality; association; cause specific ... See more keywords