Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram‐Negative Bacteria
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DOI: 10.1002/cbic.201600532
Abstract: Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram‐negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU‐N44, was investigated against… read more here.
Keywords: motuporamine derivatives; agents antibiotic; antimicrobial agents; gram negative ... See more keywords
Amino Acid Based Antimicrobial Agents - Synthesis and Properties.
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DOI: 10.1002/cmdc.202100503
Abstract: Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity,… read more here.
Keywords: agents synthesis; acid based; amino acid; antimicrobial agents ... See more keywords
Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents
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DOI: 10.1002/cmdc.202100714
Abstract: Due to the ever‐increasing antimicrobial resistance there is an urgent need to continuously design and develop novel antimicrobial agents. Inspired by the broad antibacterial activities of various heterocyclic compounds such as 2‐quinolone derivatives, we designed… read more here.
Keywords: design synthesis; quinolone; quinolone alaninate; antimicrobial agents ... See more keywords
Design, synthesis, and biological evaluation of 1,8‐naphthyridine glucosamine conjugates as antimicrobial agents
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DOI: 10.1002/ddr.21508
Abstract: In the quest for discovering potent antimicrobial agents with lower toxicity, we envisioned the design and synthesis of nalidixic acid‐D‐(+)‐glucosamine conjugates. The novel compounds were synthesized and evaluated for their in vitro antimicrobial activity against… read more here.
Keywords: design synthesis; activity; glucosamine conjugates; antimicrobial agents ... See more keywords
Discovery and structure-activity relationships of the quinolinequinones: Promising antimicrobial agents and mode of action evaluation.
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DOI: 10.1002/ddr.21893
Abstract: In our pursuit of developing the novel, potent, and selective antimicrobial agents, we managed to obtain the quinolinequinone for their antimicrobial profile with minimal inhibitory concentrations (MICs) determined against a panel of seven bacterial strains… read more here.
Keywords: activity; structure activity; mode action; antimicrobial agents ... See more keywords
An Injectable System for Local and Sustained Release of Antimicrobial Agents in the Periodontal Pocket.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700103
Abstract: Periodontitis treatments usually require local administration of antimicrobial drugs with the aim to reduce the bacterial load inside the periodontal pocket. Effective pharmaceutical treatments may require sustained local drug release for several days in the… read more here.
Keywords: system; antimicrobial agents; release antimicrobial; sustained release ... See more keywords
Meloxicam inhibits biofilm formation and enhances antimicrobial agents efficacy by Pseudomonas aeruginosa
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DOI: 10.1002/mbo3.545
Abstract: Microbial biofilms are communities of surface‐adhered cells enclosed in a matrix of extracellular polymeric substances. Bacterial cells in biofilm are 10~1,000‐fold more resistant to antimicrobials than the planktonic cells. Burgeoning antibiotic resistance in Pseudomonas aeruginosa… read more here.
Keywords: pseudomonas aeruginosa; antimicrobial agents; meloxicam; biofilm formation ... See more keywords
Antibacterial Carbon Dots-Based Composites.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207385
Abstract: The emergence and global spread of bacterial resistance to conventionally used antibiotics have highlighted the urgent need for new antimicrobial agents that might replace antibiotics. Currently, nanomaterials hold considerable promise as antimicrobial agents in anti-inflammatory… read more here.
Keywords: cds based; based composites; antibacterial carbon; carbon dots ... See more keywords
Cytotoxicity Assays as Predictors of the Safety and Efficacy of Antimicrobial Agents.
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DOI: 10.1007/978-1-4939-6634-9_6
Abstract: The development of safe antimicrobial agents is important for the effective treatment of pathogens. From a multitude of discovered inhibitory compounds only few antimicrobial agents are able to enter the market. Many antimicrobials are, on… read more here.
Keywords: predictors safety; cytotoxicity assays; assays predictors; antimicrobial agents ... See more keywords
Heterocyclic Alkaloids as Antimicrobial Agents of Aspergillus fumigatus D Endophytic on Edgeworthia chrysantha
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DOI: 10.1007/s10600-018-2365-4
Abstract: Growing evidence indicates that endophytes are among the new prolific producers of bioactive natural products [1]. In our screening of antimicrobial endophytes from Edgeworthia chrysantha Lindl., a traditional Chinese medicinal plant used to treat swelling… read more here.
Keywords: antimicrobial activities; heterocyclic alkaloids; antimicrobial agents; alkaloids antimicrobial ... See more keywords
Natural Antioxidant and Antimicrobial Agents from Agrowastes: An Emergent Need to Food Packaging
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DOI: 10.1007/s12649-018-0498-0
Abstract: Various bioactive agrowastes derived phenolic compounds (APCs) obtained from agrowastes lignin hydrolyzed methods and evaluated for their potential antioxidant, antimicrobial and anti-quorum activities with special reference to food borne pathogens. Half-maximal inhibitory concentrations (IC 50… read more here.
Keywords: food packaging; agents agrowastes; antimicrobial agents; natural antioxidant ... See more keywords