Design, Synthesis, Antimicrobial Evaluation and In Silico Studies of Novel Indole Clubbed Pyrazole Linked 1,2,3‐Triazole Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70001
Abstract: A series of novel indole–pyrazole–triazole hybrids (6a–o) was synthesized using a copper(I)‐catalyzed azide‐alkyne cycloaddition (click chemistry) under microwave irradiation. The target compounds were obtained in good yields from readily available, low‐cost starting materials under simple… read more here.
Keywords: chemistry; design synthesis; antimicrobial evaluation; synthesis antimicrobial ... See more keywords
Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract
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DOI: 10.1007/s00289-017-1946-x
Abstract: This study describes the formulation of new buccoadhesive films containing Myrrh extract as a natural and safe antimicrobial agent to give a long local medication. Buccoadhesive films of Myrrh extract were developed using solvent evaporation… read more here.
Keywords: myrrh extract; buccoadhesive films; evaluation novel; antimicrobial evaluation ... See more keywords
Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10112-3
Abstract: Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to… read more here.
Keywords: triazole molecular; antimicrobial evaluation; silico studies; quinoline triazole ... See more keywords
Synthesis and antimicrobial evaluation of new glucosylimino thiazole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01617-2
Abstract: Abstractp-Sulphonic-N-propionyl aniline 3 was produced from sulphanilic acid with propionic acid under reflux for 2 h, then the compound 3 reacted with thionyl chloride and the corresponding imidoyl chloride 4 was obtained. When imidoyl chloride 4… read more here.
Keywords: antimicrobial evaluation; evaluation new; synthesis antimicrobial; new glucosylimino ... See more keywords
Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.024
Abstract: A series of new urea derivatives (3a-p) have been synthesized from readily available isocyanates and amines in good to high yields. All synthesized compounds were fully characterized using 1H NMR, 13C NMR, IR, and mass… read more here.
Keywords: docking studies; antimicrobial evaluation; evaluation new; studies antimicrobial ... See more keywords
Design, synthesis and antimicrobial evaluation of novel glycosylated-fluoroquinolones derivatives.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112513
Abstract: Herein we report the design, synthesis and biological evaluation of structurally modified ciprofloxacin, norfloxacin and moxifloxacin standard drugs, featuring amide functional groups at C-3 of the fluoroquinolone scaffold. In vitro antimicrobial testing against various Gram-positive bacteria,… read more here.
Keywords: design synthesis; evaluation novel; antimicrobial evaluation; evaluation ... See more keywords
Design, synthesis and antimicrobial evaluation of thioglycosides of a novel class of 2-mercaptonicotinonitriles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2020.11.001
Abstract: Abstract A new class of thioglycosides comprising a diazenyl pyridine moiety was assembled from the regioselective reaction of the acetylated α-glycopyranosyl bromide with hitherto unreported 2-mercaptonicotinonitriles. Moreover, the deacetylation of S-glycoside derivatives utilizing of methanolic… read more here.
Keywords: design synthesis; evaluation thioglycosides; class; antimicrobial evaluation ... See more keywords
Design, synthesis, antimicrobial evaluation and docking studies of urea-triazole-amide hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128234
Abstract: Abstract A series of urea-1,2,3-triazole-amide hybrids was designed and synthesized via click reaction of urea derivatives containing a propargyl unit with 2-bromo-N-phenylacetamide derivatives and characterized by FTIR, NMR and HRMS data. The antimicrobial evaluation of… read more here.
Keywords: docking studies; antimicrobial evaluation; amide hybrids; urea triazole ... See more keywords
Characterization and antimicrobial evaluation of anthraquinones and triterpenes from Rubia cordifolia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2193698
Abstract: Chemical investigation of roots of the plant, Rubia cordifolia Linn, led to the isolation of an undescribed anthraquinone, cordifoquinone R, determined as 1,2-dihydroxy-6-methoxyanthracene-9,10-dione (6) based on the 1D and 2D NMR analyses and HRESIMS. Ten… read more here.
Keywords: antimicrobial evaluation; triterpenes rubia; characterization antimicrobial; evaluation anthraquinones ... See more keywords
First total synthesis and antimicrobial evaluation of xanthone V1.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2025.2581720
Abstract: Antibiotic resistance demands new agents. We disclosed the first total synthesis of the natural xanthone V1 (1), which featured a regioselective Claisen cyclization and a Claisen/Cope rearrangement that installed the pyran ring and isopentenyl unit.… read more here.
Keywords: total synthesis; first total; antimicrobial evaluation; synthesis antimicrobial ... See more keywords
Synthesis, Characterization, and Antimicrobial Evaluation of Some New 1,4-Dihydropyridines-1,2,4-Triazole Hybrid Compounds
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DOI: 10.1080/10406638.2020.1720751
Abstract: Many 1,4-dihydropyridines hybrid with 1,2,4-triazole 4a-l were synthesized by the reaction of 5,5′-(2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-diyl)bis(4-amino-4H-1,2,4-triazole-3-thiol) (2) wit... read more here.
Keywords: new dihydropyridines; compounds synthesis; characterization antimicrobial; antimicrobial evaluation ... See more keywords