Improving the Hemocompatibility of Antimicrobial Peptidomimetics through Amphiphilicity Masking Using a Secondary Amphiphilic Polymer
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DOI: 10.1002/adhm.202200546
Abstract: Antimicrobial peptidomimetics (AMPMs) have received widespread attention as potentially powerful weapons against antibiotic resistance. However, AMPMs’ membrane disruption mechanism not only brings resistance‐resistant nature, but also nonspecific binding and disruption toward eukaryotic cell membranes, and… read more here.
Keywords: improving hemocompatibility; antimicrobial peptidomimetics; amphiphilic polymer; amphiphilicity ... See more keywords
Pyrazole derived ultra-short antimicrobial peptidomimetics with potent anti-biofilm activity.
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DOI: 10.1016/j.ejmech.2016.09.071
Abstract: In this study, we report on the first chemical synthesis of ultra-short pyrazole-arginine based antimicrobial peptidomimetics derived from the newly synthesized N-alkyl/aryl pyrazole amino acids. Through the systematic tuning of hydrophobicity, charge, and peptide length,… read more here.
Keywords: antimicrobial peptidomimetics; anti biofilm; ultra short; biofilm activity ... See more keywords
Bioinspired Polydopamine Coatings Facilitate Attachment of Antimicrobial Peptidomimetics with Broad-Spectrum Antibacterial Activity
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DOI: 10.3390/ijms23062952
Abstract: The prevention and treatment of biofilm-mediated infections remains an unmet clinical need for medical devices. With the increasing prevalence of antibiotic-resistant infections, it is important that novel approaches are developed to prevent biofilms forming on… read more here.
Keywords: antibacterial activity; medical devices; bioinspired polydopamine; antimicrobial peptidomimetics ... See more keywords
Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics
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DOI: 10.3390/ijms24076407
Abstract: Antibiotic resistance is one of the most significant issues encountered in global health. There is an urgent demand for the development of a new generation of antibiotic agents combating the emergence of drug resistance. In… read more here.
Keywords: lipidated dendrimeric; short lipidated; antimicrobial peptidomimetics; aapeptides new ... See more keywords