Tubulin targeted antimitotic agents based on adamantane lead compound: synthesis, SAR and molecular modeling
Sign Up to like & getrecommendations! Published in 2020 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2020.07.005
Abstract: 5-Hydroxymethyl-2-methoxyphenyl adamantane-1-acetate inhibits cell proliferation and stimulates depolymerization of microtubules of cancer cells to free tubulin. Its analogues were synthesized via the Steglich or Mitsunobu reactions to determine the role of structural subunits of the… read more here.
Keywords: lead compound; targeted antimitotic; antimitotic agents; compound ... See more keywords
Photopharmacology of Antimitotic Agents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105657
Abstract: Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics… read more here.
Keywords: antimitotic agents; cell; photopharmacology antimitotic; microtubule ... See more keywords