Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors.
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DOI: 10.1021/acs.jmedchem.2c01116
Abstract: Protein-protein interactions play a crucial role in microtubule dynamics. Microtubules are considered as a key target for the design and development of anticancer therapeutics, where inhibition of tubulin-tubulin interactions plays a crucial role. Here, we… read more here.
Keywords: evolution potential; stapled peptide; potential antimitotic; tubulin ... See more keywords