3D QSAR studies on amphiphilic indoles for antimycobacterial activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22675
Abstract: A persistent infection prolongs treatment duration and also enhances the chance of resistance development against antibiotics. Recently, a class of amphiphilic indole derivatives was discovered exhibiting bactericidal activity against both growing and nongrowing Mycobacterium bovis… read more here.
Keywords: studies amphiphilic; antimycobacterial activity; amphiphilic indoles; qsar studies ... See more keywords
QSAR of antimycobacterial activity of benzoxazoles by optimal SMILES-based descriptors
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DOI: 10.1007/s00044-017-2013-8
Abstract: The CORAL software based on the optimal descriptors calculated with simplified molecular input-line entry system was used to build up quantitatively structure-activity relationship for the minimal inhibition concentrations against (i) Mycobacterium tuberculosis H37RV ATCC 27294… read more here.
Keywords: antimycobacterial activity; optimal smiles; activity benzoxazoles; qsar antimycobacterial ... See more keywords
New indole and indazole derivatives as potential antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02293-w
Abstract: AbstractThe study reports on the synthesis and in vitro assessment of the antimycobacterial activity of a series of new indole- and indazole-based aroylhydrazones evaluated against Mycobacterium tuberculosis H37Rv. Isoniazide and ethambutol were used as reference… read more here.
Keywords: indole indazole; antimycobacterial activity; new indole; indazole derivatives ... See more keywords
Synthesis and antimycobacterial activity of pyridinium compounds with sulfonylacetamide substituent in N-alkyl chain
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2362-3
Abstract: Pyridines containing amine, amide, or hydrazide substituent were quaternized with (ω-haloalkyl)sulfonylacetamides, resulting in new pyridinium compounds that exhibited tuberculostatic activity against the strain H37Rv of Mycobacterium tuberculosis. read more here.
Keywords: pyridinium compounds; antimycobacterial activity; substituent; synthesis antimycobacterial ... See more keywords
Analogues of Human Granulysin as Antimycobacterial Agents
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DOI: 10.1007/s10989-018-9715-8
Abstract: Antimicrobial peptides are essential components of innate defense mechanisms and make promising candidates for novel anti-infective agents. The advantages of these peptides in clinical applications include their potential for broad-spectrum and rapid bactericidal activities, and… read more here.
Keywords: antimycobacterial activity; antimycobacterial agents; granulysin antimycobacterial; human granulysin ... See more keywords
Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model
Sign Up to like & getrecommendations! Published in 2018 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-018-0152-3
Abstract: The Phytochemical investigation on MeOH extract on the bark of Aristolochia brasiliensis Mart. & Zucc (Aristolochiaceae) led to the isolation of major compound (1) as light brown grainy crystals. The compound was identified as 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol… read more here.
Keywords: antimycobacterial activity; higenamine; mellonella; model ... See more keywords
Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
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DOI: 10.1016/j.cclet.2018.08.005
Abstract: Abstract We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N-(pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, A11, C1… read more here.
Keywords: synthesis antimycobacterial; design synthesis; nitrobenzamide derivatives; antimycobacterial activity ... See more keywords
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.
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DOI: 10.1016/j.ejmech.2017.11.035
Abstract: A series of A-ring azepanones and azepanes derived from betulonic, oleanonic and ursonic acids was synthesized and evaluated for their in vitro antimycobacterial activities against M. tuberculosis (MTB) H37Rv and SDR-TB in the National Institute of Allergy… read more here.
Keywords: antimycobacterial activity; mtb h37rv; activity triterpeni; triterpeni ring ... See more keywords
Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.067
Abstract: A series of β-d-ribofuranosyl coumarinyl-1,2,3-triazoles have been synthesized by Cu-catalyzed cycloaddition reaction between azidosugar and 7-O-/7-alkynylated coumarins in 62-70% overall yields. The in vitro antimycobacterial activity evaluation of the synthesized triazolo-conjugates against Mycobacterium tuberculosis revealed that… read more here.
Keywords: antimycobacterial activity; ribofuranosyl; inha dna; dna gyrase ... See more keywords
New Isoflavonoids from the extract of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC. and their antimycobacterial activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.05.019
Abstract: ETHNOPHARMACOLOGY RELEVANCE The evaluation of the antimycobacterial activity of extracts of medicinal plants used by Mayos against tuberculosis and respiratory problems, allowed the identification of Rhynchosia precatoria (Humb. & Bonpl. ex Willd.) DC (Fabaceae) as… read more here.
Keywords: antimycobacterial activity; rhynchosia precatoria; precatoria humb; tuberculosis ... See more keywords
Anthelmintic and antimycobacterial activity of fractions and compounds isolated from Cissampelos mucronata.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115130
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Cissampelos mucronata A. Rich., a perennial climber belonging to the family Menispermaceae, has been used traditionally to treat parasites and tuberculosis-related symptoms. Co-infection of helminth parasites and tuberculosis-causing pathogens heightens the risk of… read more here.
Keywords: anthelmintic antimycobacterial; antimycobacterial activity; cissampelos mucronata; fractions compounds ... See more keywords