Bioevaluation of quinoline‐4‐carbonyl derivatives of piperazinyl‐benzothiazinones as promising antimycobacterial agents
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200168
Abstract: The quinoline moiety remains a privileged antitubercular (anti‐TB) pharmacophore, whereas 8‐nitrobenzothiazinones are emerging potent antimycobacterial agents with two investigational candidates in the clinical pipeline. Herein, we report the synthesis and bioevaluation of 30 piperazinyl‐benzothiazinone‐based quinoline… read more here.
Keywords: quinoline carbonyl; carbonyl derivatives; bioevaluation quinoline; antimycobacterial agents ... See more keywords
Analogues of Human Granulysin as Antimycobacterial Agents
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DOI: 10.1007/s10989-018-9715-8
Abstract: Antimicrobial peptides are essential components of innate defense mechanisms and make promising candidates for novel anti-infective agents. The advantages of these peptides in clinical applications include their potential for broad-spectrum and rapid bactericidal activities, and… read more here.
Keywords: antimycobacterial activity; antimycobacterial agents; granulysin antimycobacterial; human granulysin ... See more keywords
Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents.
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DOI: 10.1016/j.ejmech.2020.112659
Abstract: As the last enzyme in nucleotide synthesis as precursors for DNA replication, thymidylate kinase of M. tuberculosis (MtbTMPK) attracts significant interest as a target in the discovery of new anti-tuberculosis agents. Earlier, we discovered potent MtbTMPK… read more here.
Keywords: antimycobacterial agents; mtbtmpk inhibitors; tuberculosis; thymidylate kinase ... See more keywords