Toll-like receptors change morphine-induced antinociception, tolerance and dependence: Studies using male and female TLR and signalling gene KO mice
Sign Up to like & getrecommendations! Published in 2022 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2022.02.001
Abstract: Toll-like receptors (TLR) have been proposed as a site of action that alters opioid pharmacodynamics. However, a comprehensive assessment of acute opioid antinociception, tolerance and withdrawal behaviours in genetic null mutant strains with altered innate… read more here.
Keywords: antinociception; antinociception tolerance; like receptors; tlr signalling ... See more keywords
[Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report].
Sign Up to like & getrecommendations! Published in 2020 at "Revista brasileira de anestesiologia"
DOI: 10.1016/j.bjan.2020.07.005
Abstract: BACKGROUND Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined. Personalizing intraoperative opioid-free infusions with a nociception monitor may be the solution. CASE REPORT We… read more here.
Keywords: nociception; analgesia nociception; antinociception; opioid free ... See more keywords
Guiding opioid-free intravenous antinociception with the Analgesia Nociception Index: a case report
Sign Up to like & getrecommendations! Published in 2020 at "Revista Brasileira De Anestesiologia"
DOI: 10.1016/j.bjane.2020.07.010
Abstract: Abstract Background Opioid-free anesthesia decreases the incidence of opioid adverse events, but its optimal antinociceptive depth has not been clearly defined. Personalizing intraoperative opioid-free infusions with a nociception monitor may be the solution. Case report… read more here.
Keywords: nociception; analgesia nociception; antinociception; opioid free ... See more keywords
Alterations in nociception and morphine antinociception in mice fed a high-fat diet
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.06.019
Abstract: Currently, more than 78.6 million adults in the United States are obese. A majority of the patient population receiving treatment for pain symptoms is derived from this subpopulation. Environmental factors, including the increased availability of… read more here.
Keywords: morphine; high fat; antinociception; mice ... See more keywords
Effect of the morphine/heroin vaccine on opioid and non-opioid drug-induced antinociception in mice.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173718
Abstract: Pain is a common symptom in patients with opioid use disorder (OUD), which increases synthetic and illicit synthetic opioid abuse and even fatalities due to opioid overdose. Many FDA-approved drugs are available for the treatment… read more here.
Keywords: non opioid; morphine heroin; antinociception; vaccine ... See more keywords
Comparative study of dezocine, pentazocine and tapentadol on antinociception and physical dependence.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119996
Abstract: AIMS Dezocine and pentazocine, widely prescribed in China for postoperative pain, were initially considered as mixed agonist/antagonist targeting μ-opioid receptors (MORs) and κ-opioid receptors (KORs). However, dezocine has been revealed to alleviate chronic neuropathic pain… read more here.
Keywords: pentazocine; dezocine pentazocine; tapentadol; antinociception ... See more keywords
Evaluation of sedative and antinociceptive effects of dexmedetomidine, midazolam and dexmedetomidine-midazolam in tegus (Salvator merianae).
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2017.12.004
Abstract: OBJECTIVE To evaluate dexmedetomidine, midazolam and dexmedetomidine-midazolam for sedation and antinociception in tegus. STUDY DESIGN Prospective, crossover, randomized, blinded study. ANIMALS Six healthy tegus (Salvator merianae) weighing 1.6±0.3 kg. METHODS Tegus were administered intramuscularly saline (0.5 mL;… read more here.
Keywords: sedation; antinociception; midazolam dexmedetomidine; dexmedetomidine midazolam ... See more keywords
The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats
Sign Up to like & getrecommendations! Published in 2019 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000722
Abstract: Introduction: This study aimed to evaluate the effects of aging on hydromorphone-induced thermal antinociception in cats. Methods: In a prospective, randomized, blinded, controlled design, 10 healthy female cats received each of the following treatments intramuscularly:… read more here.
Keywords: aging hydromorphone; effects aging; antinociception; hydromorphone induced ... See more keywords
Negative modulation of spinal κ-opioid receptor-mediated antinociception by the µ-opioid receptor at selective doses of (−)-pentazocine
Sign Up to like & getrecommendations! Published in 2018 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001043
Abstract: The mixed-action &kgr;-opioid receptor (KOR) agonist, pentazocine, binds to both KOR and the µ-opioid receptor (MOR). Racemic (±)-pentazocine and (−)-pentazocine, each administered systemically, have been shown to produce antinociception in various animal models. In contrast,… read more here.
Keywords: pentazocine; antinociception; opioid receptor; mor ... See more keywords
CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca lancehead pit vipers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221115755
Abstract: Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted increasing clinical interest and consist in a new perspective for treating some neurological and psychiatric diseases. Aims: The aim of this work was to investigate… read more here.
Keywords: antinociception; bothrops jararaca; mice threatened; cbd ... See more keywords
Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.968976
Abstract: Korean scientists have shown that oral administration of Angelica gigas Nakai (AGN) root alcoholic extract and the metabolite of its pyranocoumarins, decursinol, have antinociceptive properties across various thermal and acute inflammatory pain models. The objectives… read more here.
Keywords: antinociception; pain models; neuropathic pain; tolerance ... See more keywords