Nanocapsules improve indole‐3‐carbinol photostability and prolong its antinociceptive action in acute pain animal models
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.09.050
Abstract: ABSTRACT This study aimed the development of nanocapsules (NCs) for oral indole‐3‐carbinol (I3C) administration and evaluation of antinociceptive potential of this compound in its two forms, free and nanoencapsulated, using acute pain models. NCs showed… read more here.
Keywords: antinociceptive action; acute; action acute; acute pain ... See more keywords
Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107826
Abstract: Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion. The spider toxin PnTx3-5, native or recombinant, and SB-366791 PnTx3-5 is thus more potent than the selective TRPV1 blocker… read more here.
Keywords: trpv1; antinociceptive action; pntx3; toxin ... See more keywords
Antinociceptive Action of Thymoquinone-Loaded Liposomes in an In Vivo Model of Tendinopathy
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051516
Abstract: Tendinopathies represent about 45% of musculoskeletal lesions and they are a big burden in clinics characterized by activity-related pain, focal tendon tenderness and intra-tendinous imaging changes. Many approaches have been proposed for tendinopathies’ management (e.g.,… read more here.
Keywords: action thymoquinone; thymoquinone loaded; antinociceptive action; model tendinopathy ... See more keywords