Synthesis and antinociceptive activity of four 1H‐isoindolo‐1,3(2H)‐diones
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100423
Abstract: The present study aimed to design and synthesize a series of 2‐hydroxy‐3‐(4‐aryl‐1‐piperazinyl)propyl phthalimide derivatives, which are analogs of 1H‐pyrrolo[3,4‐c]pyridine‐1,3(2H)‐dione derivatives with proven analgesic effect. In accordance with the basic principle proposed by Lipinski's rule, the… read more here.
Keywords: antinociceptive activity; four isoindolo; synthesis antinociceptive; isoindolo diones ... See more keywords
Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01285
Abstract: The TWIK-related K+ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here, we… read more here.
Keywords: twik related; channel; antinociceptive activity; related channel ... See more keywords
Erratum: Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception.
Sign Up to like & getrecommendations! Published in 2020 at "Planta medica"
DOI: 10.1055/a-1170-9487
Abstract: The antinociceptive property of Centella asiatica extracts is known but the analgesic activity of its bioactive constituent asiaticoside has not been reported. We evaluated the antinociceptive activity of orally (p. o.) administered asiaticoside (1, 3, 5,… read more here.
Keywords: erratum antinociceptive; activity; activity asiaticoside; antinociceptive activity ... See more keywords
Chemical composition and evaluation of antinociceptive activity of the essential oil of Stevia serrata Cav. from Guatemala
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2017.1399376
Abstract: Abstract The composition and the antinociceptive activity of the essential oil of Stevia serrata Cav. from a population located in the west highlands of Guatemala were evaluated. A yield of 0.2% (w/w) of essential oil… read more here.
Keywords: essential oil; antinociceptive activity; serrata cav; oil ... See more keywords
Antinociceptive activity of the ethanolic extract of Trixis angustifolia DC.
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DOI: 10.1080/14786419.2021.2017931
Abstract: The antinociceptive activity of the ethanolic extract of Trixis angustifolia DC. (EETx) was investigated using the acetic acid-induced writhing and the hot-plate tests in mice. In the acetic acid-induced writhing test, mice treated with EETx… read more here.
Keywords: ethanolic extract; antinociceptive activity; extract trixis; activity ethanolic ... See more keywords
Potent nonopioid antinociceptive activity of telocinobufagin in models of acute pain in mice
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DOI: 10.1097/pr9.0000000000000791
Abstract: Abstract Introduction: In recent decades, several researches have been conducted in search of new analgesics that do not present the side effects of opioids. In this context, animal venoms contain natural painkillers that have been… read more here.
Keywords: mice; pain; tcb; antinociceptive activity ... See more keywords
Antinociceptive Activity of Petroleum Ether Fraction of Clinacanthus nutans Leaves Methanolic Extract: Roles of Nonopioid Pain Modulatory Systems and Potassium Channels
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/6593125
Abstract: Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been reported to exert antinociceptive activity. The present study aimed to elucidate the possible antinociceptive mechanisms of a lipid-soluble fraction of MECN, which was obtained after… read more here.
Keywords: pecn; fraction; antinociceptive activity; petroleum ether ... See more keywords
Development of Ecofriendly Carbon Dots for Improving Solubility and Antinociceptive Activity of Glycyrrhizic Acid.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2021.3058
Abstract: The therapeutic potential of glycyrrhizic acid (GA) with various pharmacological properties is extremely limited owing to its poor water solubility. To solve this problem, nanocarrier-nontoxic Glycyrrhizae Radix et Rhizoma-derived carbon dots (GRR-CDs) with a narrow… read more here.
Keywords: antinociceptive activity; grr cds; glycyrrhizic acid; carbon dots ... See more keywords
β–Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052692
Abstract: Transient receptor potential melastatin subtype 8 (TRPM8) is a cation channel extensively expressed in sensory neurons and implicated in different painful states. However, the effectiveness of TRPM8 modulators for pain relief is still a matter… read more here.
Keywords: antinociceptive activity; trpm8 antagonist; rgm8; activity ... See more keywords