Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.
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DOI: 10.1016/j.ejphar.2020.173021
Abstract: Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine. We evaluated the acute and chronic effects of M3G… read more here.
Keywords: substance; antinociceptive cross; cross tolerance; m3g ... See more keywords