Anti‐inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae)
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DOI: 10.1002/ddr.21432
Abstract: Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia. The in vitro anti‐inflammatory effects of TFD (0.1–200 µM) were assessed using… read more here.
Keywords: anti inflammatory; tfd; antinociceptive effects; salvia tiliifolia ... See more keywords
In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05595-9
Abstract: Animal studies and anecdotal human reports suggest that cannabinoids have antinociceptive effects. Controlled human studies have produced mixed results. We sought to reduce existing variability by investigating the effects of intravenous delta-9-tetrahydrocannabinol (THC) in several… read more here.
Keywords: healthy human; antinociceptive effects; study; delta tetrahydrocannabinol ... See more keywords
Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.11.012
Abstract: OBJECTIVE This study aimed to investigate the antinociceptive effects of the selective adenylyl cyclase type 1 (AC1) inhibitor ST034307 on tooth movement nociception through orofacial nociceptive behavior tests and molecular examination. METHODS We placed fixed… read more here.
Keywords: movement; nociception; adenylyl cyclase; tooth movement ... See more keywords
Structurally diverse diterpenoids with eight carbon skeletons from Rhododendron micranthum and their antinociceptive effects.
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DOI: 10.1016/j.bioorg.2021.104870
Abstract: Seventeen diterpenoids (1-17), classified into eight diverse carbon skeleton types, grayanane (1, 2, and 12), micranthane (3, 4, and 13), mollane (5-7 and 14), 1,5-seco-grayanane (8), kalmane (9-11), 1,5-seco-kalmane (15), A-homo-B-nor-ent-kaurane (16), and leucothane (17),… read more here.
Keywords: rhododendron micranthum; carbon; antinociceptive effects; seco kalmane ... See more keywords
Antinociceptive effects of a hydroethanolic stem bark extract of Burkea africana
Sign Up to like & getrecommendations! Published in 2022 at "Heliyon"
DOI: 10.1016/j.heliyon.2022.e08917
Abstract: Introduction Pain is a major symptom of many clinical disorders and its relief has long been a concern for individuals across the globe. There is therefore an unmet need to search for new efficacious agents… read more here.
Keywords: burkea africana; stem bark; bae; pain ... See more keywords
Antinociceptive effects of levomethadone in standing horses sedated with romifidine.
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DOI: 10.1016/j.vaa.2020.08.011
Abstract: OBJECTIVE To evaluate the antinociceptive effect of a bolus of intravenous levomethadone administered to horses during romifidine constant rate infusion (CRI). STUDY DESIGN Prospective, randomized, masked, crossover experimental study. ANIMALS A group of eight adult… read more here.
Keywords: levomethadone administration; levomethadone; effects levomethadone; antinociceptive effects ... See more keywords
Antinociceptive Grayanane Diterpenoids from the Leaves of Pieris japonica.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00569
Abstract: Thirteen new grayanane diterpenoids (1-13) and 15 known analogues (14-28) were isolated from a leaf extract of Pieris japonica. Their structures were determined by spectrometric and spectroscopic methods, including HRESIMS, NMR, IR, and UV. The… read more here.
Keywords: pieris japonica; antinociceptive effects; grayanane diterpenoids; antinociceptive grayanane ... See more keywords
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4185393
Abstract: Tropomyosin receptor kinase A (TrkA) is considered a therapeutic target in pain treatment, and several TrkA inhibitors have been designed and developed as potential analgesics. The subselectivity toward TrkA is closely associated with safety and… read more here.
Keywords: design development; antinociceptive effects; inhibitor; trka ... See more keywords
CLINICAL AND ANTINOCICEPTIVE EFFECTS OF DISTAL INFERIOR ALVEOLAR NERVE BLOCK IN PONIES WITH TRAMADOL 5% OR LIDOCAINE 2.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of equine veterinary science"
DOI: 10.2139/ssrn.4237294
Abstract: This study aimed to compare the antinociceptive effects of tramadol 5% and lidocaine 2% on mental nerve block in horses of the Brazilian Pony breed. Eight adult non-pregnant mares were used in this study. The… read more here.
Keywords: antinociceptive effects; arterial pressure; nerve block; tramadol lidocaine ... See more keywords
Evaluation of the thermal antinociceptive effects of hydromorphone hydrochloride after intramuscular administration to orange-winged Amazon parrots (Amazona amazonica).
Sign Up to like & getrecommendations! Published in 2020 at "American journal of veterinary research"
DOI: 10.2460/ajvr.81.10.775
Abstract: OBJECTIVE To evaluate the thermal antinociceptive effects of hydromorphone hydrochloride after IM administration to orange-winged Amazon parrots (Amazona amazonica). ANIMALS 8 healthy adult parrots (4 males and 4 females). PROCEDURES In a randomized crossover study,… read more here.
Keywords: effects hydromorphone; administration; hydromorphone hydrochloride; antinociceptive effects ... See more keywords
In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmaceutica"
DOI: 10.2478/acph-2018-0029
Abstract: Abstract The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus,… read more here.
Keywords: basis creme; wolff basis; antinociceptive effects; vivo investigation ... See more keywords