Selective mitochondrial antioxidant MitoTEMPO reduces renal dysfunction and systemic inflammation in experimental sepsis.
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DOI: 10.1016/j.bja.2021.05.036
Abstract: BACKGROUND Excess mitochondrial reactive oxygen species (mROS) in sepsis is associated with organ failure, in part by generating inflammation through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome. We determined the impact of… read more here.
Keywords: sepsis; renal dysfunction; dysfunction; antioxidant mitotempo ... See more keywords