Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09581-7
Abstract: Doxorubicin (DOX) is a widely prescribed anthracycline antineoplastic drug for treating human solid tumors and leukemias. However, DOX therapy is limited by a cumulative, dose-dependent, and irreversible cardiomyopathy that occurs with repeated administration. Presumably, a… read more here.
Keywords: response system; antioxidant response; keap1 nrf2; response ... See more keywords
Effects of a single trace mineral injection at beginning of fixed-time AI treatment regimen on reproductive function and antioxidant response of grazing Nellore cows.
Sign Up to like & getrecommendations! Published in 2019 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2019.106234
Abstract: Two experiments evaluated the effects of injectable trace minerals (ITM) administered 11 d before artificial insemination (AI) on body weight (BW), body condition score (BCS), ovarian structures, pregnancy rate, and antioxidant response of Nellore cows.… read more here.
Keywords: antioxidant response; response; nellore cows; treatment ... See more keywords
Yap1 homologs mediate more than the redox regulation of the antioxidant response in filamentous fungi.
Sign Up to like & getrecommendations! Published in 2020 at "Fungal biology"
DOI: 10.1016/j.funbio.2019.04.001
Abstract: The regulation of gene expression in response to increased levels of reactive oxygen species (ROS) is a ubiquitous response in aerobic organisms. However, different organisms use different strategies to perceive and respond to high ROS… read more here.
Keywords: response; regulation; filamentous fungi; antioxidant response ... See more keywords
Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.04.038
Abstract: Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of… read more here.
Keywords: state; redox homeostasis; antioxidant response; nrf2 ... See more keywords
Antioxidant response elements: Discovery, classes, regulation and potential applications
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.05.002
Abstract: Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer protection against oxidative stress. This articulated universal mechanism is regulated through the… read more here.
Keywords: antioxidant response; oxidative stress; elements discovery; regulation ... See more keywords
The antioxidant response in Barrett's tumorigenesis: A double-edged sword
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101894
Abstract: Esophageal adenocarcinoma (EAC) is the dominant form of esophageal malignancies in the United States and other industrialized countries. The incidence of EAC has been rising rapidly during the past four decades. Barrett's esophagus (BE) is… read more here.
Keywords: response barrett; tumorigenesis; antioxidant response; response ... See more keywords
Regulation of the Antioxidant Response by MyoD Transcriptional Coactivator in Castration-resistant Prostate Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Urology"
DOI: 10.1016/j.urology.2018.04.028
Abstract: OBJECTIVE To reveal the potential role of the basic helix-loop-helix myogenic transcription regulator MyoD in the regulation of castration-resistant prostate cancer. METHODS Expression level of MyoD was assessed in prostate cancer tissues using quantitative reverse… read more here.
Keywords: antioxidant response; prostate cancer; castration resistant;
Keap1–MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30562-y
Abstract: Coordination of DNA replication and cellular redox homeostasis mechanisms is essential for the sustained genome stability due to the sensitivity of replicating DNA to oxidation. However, substantial gaps remain in our knowledge of underlying molecular… read more here.
Keywords: antioxidant response; response; dna replication; mcm3 ... See more keywords
LRRC8A Anion Channel Knockout Stimulates the Nrf2 Antioxidant Response
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732507
Abstract: Leucine Rich Repeat Containing 8A (LRRC8A) is an essential component of volume‐regulated anion channels (VRACs), which regulate cell volume. These anion channels are activated by pro-inflammatory mediators such as angiotensin II and tumor necrosis factor-α… read more here.
Keywords: antioxidant response; lrrc8a; physiology; anion ... See more keywords
Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191547
Abstract: Objectives Oxidative stress and inflammation have been postulated as underlying mechanisms for the development of obesity-related insulin resistance. This association however, remains elusive especially in childhood. We sought to investigate this relation by measuring oxidative… read more here.
Keywords: antioxidant response; stress; insulin resistance; obesity ... See more keywords
Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and Cells"
DOI: 10.14348/molcells.2023.0005
Abstract: The transcription factor Nrf2 was originally identified as a master regulator of redox homeostasis, as it governs the expression of a battery of genes involved in mitigating oxidative and electrophilic stress. However, the central role… read more here.
Keywords: antioxidant response; ferroptotic effects; effects nrf2; nrf2 beyond ... See more keywords