MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.012
Abstract: MicroRNAs (miRNAs) have emerged as critical regulators of ischemic stroke, a condition that affects neuronal survival. However, the precise role of miRNAs in regulating neuronal injury during ischemic stroke remains largely unknown. In this study,… read more here.
Keywords: ischemic stroke; nrf2 antioxidant; glucose deprivation; antioxidant signaling ... See more keywords
Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.07.011
Abstract: Transient mitochondrial stress can promote beneficial physiological responses and longevity, termed "mitohormesis." To interrogate mitohormetic pathways in mammals, we generated mice in which mitochondrial superoxide dismutase 2 (SOD2) can be knocked down in an inducible… read more here.
Keywords: mitochondrial antioxidant; mitohormesis; activation mitochondrial; antioxidant signaling ... See more keywords
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154226
Abstract: GM‐CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated with a number of inflammatory pathologies including rheumatoid arthritis and inflammatory bowel disease. GM‐CSF has been… read more here.
Keywords: csf; antioxidant signaling; suppresses antioxidant; secretion ... See more keywords