In vitro antiplasmodial activity of Withania frutescens—Solanaceae
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Integrative Medicine"
DOI: 10.1016/j.eujim.2017.08.009
Abstract: Abstract Introduction Drugs resistant Plasmodium falciparum is a recurring issue that threatens public health. New antiplasmodial drugs are needed to overcome this problem. The aim of this study was to characterize in vitro antiplasmodial activity… read more here.
Keywords: antiplasmodial activity; frutescens solanaceae; withania frutescens; vitro antiplasmodial ... See more keywords
Antiplasmodial activity of Mezoneuron benthamianum leaves and identification of its active constituents.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.03.021
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Decoctions of the leaves of M. benthamianum Baill. are used by traditional healers in Guinea to treat malaria and this use was validated by a preliminary clinical assay. AIM OF THE STUDY To… read more here.
Keywords: antiplasmodial activity; activity; mezoneuron benthamianum; benthamianum leaves ... See more keywords
In vitro antiplasmodial and cytotoxicity activities of crude extracts and major compounds from Goniothalamus lanceolatus.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112657
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Malaria, a devastating infectious disease which was initially recognized as episodic fever, is caused by parasitic protozoan of the genus Plasmodium. Medicinal plants with ethnobotanical information to treat fever and/or malaria has been… read more here.
Keywords: goniothalamus lanceolatus; antiplasmodial activity; crude extracts; compound ... See more keywords
3D-QSAR Modeling and Synthesis of New Fusidic Acid Derivatives as Antiplasmodial Agents
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00105
Abstract: Wide spread Plasmodium falciparum ( P. falciparum) resistance has compromised existing antimalarial therapies to varying degrees. Novel agents, able to circumvent antimalarial drug resistance, are therefore needed. Fusidic acid is a unique antibiotic with a… read more here.
Keywords: new fusidic; antiplasmodial activity; acid derivatives; acid ... See more keywords
Synthesis and antiplasmodial activity of purine-based C-nucleoside analogues.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c8md00098k
Abstract: A series of homologous C-nucleoside mimics have been synthesized via an efficient and facile synthetic protocol involving the conjugate addition of purine to sugar derived olefinic ester in good yields. The synthesized compounds were evaluated… read more here.
Keywords: antiplasmodial activity; activity purine; purine based; synthesis antiplasmodial ... See more keywords
N,O-Chelating quinoline-based half-sandwich organorhodium and -iridium complexes: synthesis, antiplasmodial activity and preliminary evaluation as transfer hydrogenation catalysts for the reduction of NAD.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt02030f
Abstract: Two Rh(iii) and Ir(iii) half-sandwich quinoline-based complexes were synthesised and evaluated for their in vitro antiplasmodial activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. These half-sandwich… read more here.
Keywords: half sandwich; antiplasmodial activity; transfer; quinoline based ... See more keywords
Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2018.1553958
Abstract: Abstract One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe… read more here.
Keywords: leaves phoebe; aporphine alkaloids; antiplasmodial activity; phoebe tavoyana ... See more keywords
Phytochemistry and antiplasmodial activity of Xylopia sericea leaves
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DOI: 10.1080/14786419.2019.1577838
Abstract: Abstract Aiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass… read more here.
Keywords: sericea leaves; antiplasmodial activity; activity; xylopia sericea ... See more keywords
A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2034810
Abstract: The CH2Cl2/MeOH (1:1) extract of Zanthoxylum holstzianum stem bark showed good antiplasmodial activity (IC50 2.5 ± 0.3 and 2.6 ± 0.3 µg/mL against the W2 and D6 strains of Plasmodium falciparum, respectively). From the extract five benzophenanthridine alkaloids [8-acetonyldihydrochelerythrine (1),… read more here.
Keywords: zanthoxylum holstzianum; new linked; dimer; antiplasmodial activity ... See more keywords
Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines
Sign Up to like & getrecommendations! Published in 2019 at "Malaria Journal"
DOI: 10.1186/s12936-019-2725-y
Abstract: BackgroundMalaria is one of the most prevalent tropical infectious diseases. Since recently cases of artemisinin resistance were reported, novel anti-malarial drugs are required which differ from artemisinins in structure and biological target. The plasmodial glycogen… read more here.
Keywords: selective pfgsk; antiplasmodial activity; position; pfgsk ... See more keywords
Growth, secondary metabolite production, and in vitro antiplasmodial activity of Sonchus arvensis L. callus under dolomite [CaMg(CO3)2] treatment
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0254804
Abstract: Malaria is still a global health problem. Plasmodium is a single-cell protozoan parasite that causes malaria and is transmitted to humans through the female Anopheles mosquito. The previous study showed that Sonchus arvensis L. callus… read more here.
Keywords: production; arvensis callus; antiplasmodial activity; vitro antiplasmodial ... See more keywords