Incorporation of Trifluoromethyltriazoline in the Side Chain of 4‐Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents
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DOI: 10.1002/cmdc.202200653
Abstract: Reported herein is the identification of a novel class of 4‐aminoquinoline‐trifluormethyltriazoline compounds as possible antiplasmodial agents. The compounds were accessed through a silver‐catalyzed three‐component reaction of trifluorodiazoethane with in situ generated Schiff base from corresponding quinolinylamine… read more here.
Keywords: chain aminoquinolines; side chain; incorporation trifluoromethyltriazoline; aminoquinolines synthesis ... See more keywords
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.10.041
Abstract: Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatment… read more here.
Keywords: derivatives potent; antiplasmodial agents; quinazoline derivatives; potent antiplasmodial ... See more keywords
3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis.
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DOI: 10.1080/14786419.2021.1895149
Abstract: Malaria is an infectious illness, affecting vulnerable populations in Third World countries. Inspired by natural products, indole alkaloids have been used as a nucleus to design new antimalarial drugs. So, eighteen oxindole derivatives, aza analogues… read more here.
Keywords: indolinones derivatives; analysis; derivatives antiplasmodial; antiplasmodial agents ... See more keywords
Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents
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DOI: 10.3390/molecules24152812
Abstract: This paper describes a continuation of our efforts in the pursuit of novel antiplasmodial agents with optimized properties. Following our previous discovery of biologically potent asymmetric primaquine (PQ) and halogenaniline fumardiamides (1–6), we now report… read more here.
Keywords: fumardiamides promising; antiplasmodial agents; activity; chloroquine fumardiamides ... See more keywords
Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents
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DOI: 10.4155/fmc-2016-0215
Abstract: Aim: The recurring resistance of the malaria parasite to many drugs compels the design of innovative chemical entities in antimalarial research. Pan-histone deacetylase inhibitors (pan-HDACis) have recently been presented in the literature as powerful novel… read more here.
Keywords: hhdac6 inhibitors; antiplasmodial agents; thiaheterocyclic hhdac6; inhibitors potential ... See more keywords