Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation.
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DOI: 10.1021/acs.jmedchem.2c00592
Abstract: Sixty palmatine (PMT) derivatives were synthesized and evaluated for antiplatelet aggregation taking berberine as the lead, and the structure-activity relationship was first systematically described. Among them, compound 2v showed the best potency in reducing adenosine… read more here.
Keywords: antiplatelet aggregation; aggregation; kinase; akt phosphorylation ... See more keywords
Potential antiplatelet aggregation metabolites from the discarded sorghum (Sorghum bicolor L.) root
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DOI: 10.1080/14786419.2022.2101052
Abstract: Abstract Sorghum (Sorghum bicolor L.) is the fifth largest crop in the world and has potential health benefits, but vast quantities of sorghum roots are discarded after harvest. Based on the previous antiplatelet aggregation for… read more here.
Keywords: aggregation; sorghum; antiplatelet aggregation; sorghum sorghum ... See more keywords
Synthesis, oral bioavailability evaluation and antiplatelet aggregation activity of three derivatives of 3,4‑dihydroxyacetophenone.
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DOI: 10.3892/ijmm.2020.4469
Abstract: 3,4‑Dihydroxyacetophenone (DHAP) exerts therapeutic effects on cardiovascular disease and pulmonary heart disease. However, it is not utilized as a clinical drug due to its rapid metabolism, short‑acting effect and low oral bioavailability. In the present… read more here.
Keywords: aggregation activity; oral bioavailability; dhap; bioavailability ... See more keywords