Deletion of the N‐terminal domain of the yeast vacuolar (Na+,K+)/H+ antiporter Vnx1p improves salt tolerance in yeast and transgenic Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Yeast"
DOI: 10.1002/yea.3450
Abstract: Cation/proton antiporters play a major role in the control of cytosolic ion concentrations in prokaryotes and eukaryotes organisms. In yeast, we previously demonstrated that Vnx1p is a vacuolar monovalent cation/H+ exchanger showing Na+/H+ and K+/H+… read more here.
Keywords: terminal domain; tolerance; antiporter; yeast ... See more keywords
Expression of a Na+/H+ antiporter RtNHX1 from a recretohalophyte Reaumuria trigyna improved salt tolerance of transgenic Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2017.07.015
Abstract: Reaumuria trigyna is an endangered recretohalophyte and a small xeric shrub that is endemic to the eastern Alxa and western Ordos areas of Inner Mongolia, China. Using transcriptome data, we identified a 1662-bp open reading… read more here.
Keywords: salt tolerance; antiporter; rtnhx1; transgenic arabidopsis ... See more keywords
xCT/SLC7A11 antiporter function inhibits HIV-1 infection.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.01.008
Abstract: Human macrophages are protected by intrinsic antiviral defenses that provide moderate protection against HIV-1 infection. Macrophages that do become infected can serve as long-lived reservoirs, to disseminate HIV-1 to CD4+ T cells. Infection of macrophages… read more here.
Keywords: hiv infection; xct; xct slc7a11; antiporter ... See more keywords
Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06306-x
Abstract: Multidrug resistance (MDR) poses a major challenge to medicine. A principle cause of MDR is through active efflux by MDR transporters situated in the bacterial membrane. Here we present the crystal structure of the major… read more here.
Keywords: medicine; facilitator superfamily; antiporter; conformation ... See more keywords
Implication of the glutamate–cystine antiporter xCT in schizophrenia cases linked to impaired GSH synthesis
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-017-0035-3
Abstract: AbstractxCT is the specific chain of the cystine/glutamate antiporter, which is widely reported to support anti-oxidant defenses in vivo. xCT is therefore at the crossroads between two processes that are involved in schizophrenia: oxidative stress… read more here.
Keywords: schizophrenia; xct; antiporter; xct schizophrenia ... See more keywords
Characterization of a novel two-component Na+(Li+, K+)/H+ antiporter from Halomonas zhaodongensis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04236-0
Abstract: In this study, genomic DNA was screened for novel Na+/H+ antiporter genes from Halomonas zhaodongensis by selection in Escherichia coli KNabc lacking three major Na+/H+ antiporters. Co-expression of two genes designated umpAB, encoding paired homologous… read more here.
Keywords: novel two; halomonas zhaodongensis; antiporter; component antiporter ... See more keywords
The pH sensor and ion binding of NhaD Na+/H+ antiporter from IT superfamily
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.14965
Abstract: Sodium‐proton (Na+/H+) antiporters from the ion transporter (IT) superfamily play a vital role in controlling the pH and electrolyte homeostasis. However, very limited information regarding their structural functions is available to date. In this study,… read more here.
Keywords: binding nhad; antiporter superfamily; ion binding; sensor ion ... See more keywords
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.858462
Abstract: SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative… read more here.
Keywords: cancer; antiporter; slc7a11 xct; cystine ... See more keywords