Novel γ-lactone derivatives from Trigonostemon heterophyllus with their potential antiproliferative activities.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.04.015
Abstract: Two novel γ-lactone derivatives, trigoheterophines A (1) and B (2), together with four known furan derivatives (3-6), were isolated from the stems and leaves of Trigonostemon heterophyllus. The structures of 1 and 2 were elucidated… read more here.
Keywords: trigonostemon heterophyllus; novel lactone; lactone derivatives; antiproliferative activities ... See more keywords
Phenylpropanoid and dibenzofuran derivatives from Crataegus pinnatifida with antiproliferative activities on hepatoma cells.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103354
Abstract: Eleven aromatic compounds, including four pairs of undescribed phenylpropanoids and two undescribed dibenzofurans (1a/1b-4a/4b and 5-6), were isolated from the fruits of C. pinnatifida. Their structures were established by extensive spectroscopic analyses. Their relative and… read more here.
Keywords: dibenzofuran derivatives; derivatives crataegus; hepatoma cells; antiproliferative activities ... See more keywords
Novel 4-arylaminoquinazoline derivatives with (E)-propen-1-yl moiety as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.023
Abstract: A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were designed, synthesized and evaluated for biological activities in vitro. Most compounds exhibited highly antiproliferative activities against all tested tumor cell lines including A431, A549, NCI-H1975 and… read more here.
Keywords: egfr; derivatives propen; antiproliferative activities; novel arylaminoquinazoline ... See more keywords
Bi- and bisbibenzyls from the roots of Dichapetalum heudelotii and their antiproliferative activities.
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DOI: 10.1016/j.fitote.2017.09.001
Abstract: Two new bisbibenzyls, heudelotol A (1) and B (2), along with the known bibenzyls, (E)-combretastatin A-1 (3) and combretastatin B-1 (4) have been isolated from the ethyl acetate extract of the roots of Dichapetalum heudelotii.… read more here.
Keywords: bisbibenzyls roots; roots dichapetalum; cell lines; heudelotii antiproliferative ... See more keywords
Kombuchas from green and black teas have different phenolic profile, which impacts their antioxidant capacities, antibacterial and antiproliferative activities.
Sign Up to like & getrecommendations! Published in 2020 at "Food research international"
DOI: 10.1016/j.foodres.2019.108782
Abstract: UPLC-QTOF-MSE phenolic profile of kombuchas produced from the fermentation of green tea or black tea at 25 °C for 10 days was investigated along with the determination of their antioxidant capacities, antibacterial and antiproliferative activities. Overall, 127… read more here.
Keywords: antibacterial antiproliferative; antioxidant capacities; capacities antibacterial; phenolic profile ... See more keywords
Stereoselective synthesis of the four 16-hydroxymethyl-3-methoxy- and 16-hydroxymethyl-3-benzyloxy-13α-estra-1,3,5(10)-trien-17-ol isomers and their antiproliferative activities
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.02.008
Abstract: Graphical abstract Figure. No caption available. HighlightsStereoselective synthesis of diastereomeric diols.Straightforward synthetic route from trans‐ to cis‐diols.Substantial antiproliferative action against HeLa. &NA; The reduction of 16‐hydroxymethylene‐3‐methoxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (14) and 16‐hydroxymethylene‐3‐benzyloxy‐13&agr;‐estra‐1,3,5(10)‐trien‐17‐one (16) yielded a mixture of two… read more here.
Keywords: benzyloxy; hydroxymethyl; estra trien; antiproliferative activities ... See more keywords
Design, synthesis, and antiproliferative activities of stapled melittin peptides
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DOI: 10.1039/c6ra26427a
Abstract: Melittin is a 26-residue, amphipathic, cell-penetrating, α-helical anti-hepatoma peptide isolated from bee venom. However, the application of melittin as a drug is limited owing to its original conformational flexibility and low stability. In this study,… read more here.
Keywords: design synthesis; melittin; activities stapled; synthesis antiproliferative ... See more keywords
Phenolic content, antioxidant and antiproliferative activities of six varieties of white sesame seeds (Sesamum indicum L.)
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DOI: 10.1039/c6ra26596k
Abstract: Little work has been conducted on the evaluation of antioxidant and antiproliferative activities of different sesame seed varieties. This article compared the total phenolics, antioxidant contents, and the antiproliferative activities of six varieties of white… read more here.
Keywords: seed; sesame; antioxidant antiproliferative; sesame seeds ... See more keywords
Copper chloride complexes with substituted 4'-phenyl-terpyridine ligands: synthesis, characterization, antiproliferative activities and DNA interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Dalton transactions"
DOI: 10.1039/d0dt03989f
Abstract: Eleven copper chloride coordination compounds (1-11) with 4'-(4'-substituted-phenyl)-2,2':6',2''-terpyridine ligands bearing hydrogen (L1), cyano (L2), p-hydroxyl (L3), m-hydroxyl (L4), o-hydroxyl (L5), methoxyl (L6), iodo (L7), bromo (L8), chloro (L9), fluoro (L10) or methylsulfonyl (L11) were prepared… read more here.
Keywords: phenyl terpyridine; substituted phenyl; spectroscopy; antiproliferative activities ... See more keywords
Triterpenoids with antiproliferative activities from the twigs and leaves of Melaleuca linariifolia
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DOI: 10.1080/10286020.2020.1779708
Abstract: Abstract One new pentacyclic triterpenoid, urs-12,16-dien-3-one (1), together with twelve known pentacyclic triterpenoids (2‒13), were isolated from the twigs and leaves of Melaleuca linariifolia. Their structures were characterized by their 1D- and 2 D-NMR spectra analysis… read more here.
Keywords: twigs leaves; activities twigs; leaves melaleuca; triterpenoids antiproliferative ... See more keywords
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1933466
Abstract: Abstract In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor… read more here.
Keywords: tumour cells; preliminary structure; activities tumour; activity relationship ... See more keywords