Synthesis, structure and antiproliferative activity of organometallic iridium(III) complexes containing thiosemicarbazone ligands
Sign Up to like & getrecommendations! Published in 2017 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.3610
Abstract: A series of half-sandwich iridium complexes (1–4) with thiosemicarbazone ligands in two types of coordination modes were synthesized and characterized. The molecular structures of compounds 1, 2 and 3 were determined using single-crystal X-ray diffraction… read more here.
Keywords: iridium; thiosemicarbazone ligands; synthesis structure; structure antiproliferative ... See more keywords
Novel pyrazolopyrimidine urea derivatives: Synthesis, antiproliferative activity, VEGFR‐2 inhibition, and effects on the cell cycle profile
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DOI: 10.1002/ardp.201900319
Abstract: A series of novel diaryl urea pyrazolopyrimidine derivatives was designed and synthesized. All the synthesized compounds were evaluated for cytotoxic activity by the National Cancer Institute. A significant antiproliferative activity at a 10‐µM dose was… read more here.
Keywords: cell cycle; pyrazolopyrimidine; antiproliferative activity; vegfr ... See more keywords
Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000466
Abstract: In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97%… read more here.
Keywords: benzyloxy; benzyloxy dihydropyrimidinones; antiproliferative benzyloxy; study ... See more keywords
Structural properties and evaluation of the antiproliferative activity of limonene-1,2-diol obtained by the fungal biotransformation of R-(+)- and S-(-)-limonene.
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DOI: 10.1002/chir.23439
Abstract: Limonene-1,2-diol is a limonene oxygenated metabolite that possesses eight different stereoisomers, which could result in different biological properties. Nonetheless, the relation between its spatial configuration and biological function is still little explored. The present study… read more here.
Keywords: limonene; limonene biotransformation; limonene diol; antiproliferative activity ... See more keywords
A Focused Library of NO‐Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900385
Abstract: Cancer is the second leading cause of death worldwide. Herein, a strategy to quickly and efficiently identify novel lead compounds to develop anticancer agents, using green multicomponent reactions followed by antiproliferative activity and structure–activity relationship… read more here.
Keywords: multicomponent reactions; green multicomponent; focused library; potent antiproliferative ... See more keywords
1,2,4‐Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase
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DOI: 10.1002/cmdc.202000752
Abstract: A new series of topsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,2,4‐oxadiazole moiety, was efficiently synthesized. All derivatives were pre‐screened for antiproliferative activity against the National… read more here.
Keywords: oxadiazole topsentin; topsentin analogs; antiproliferative activity; cancer ... See more keywords
Synthesis, in vitro antiproliferative activity, antioxidant activity and molecular modeling studies of new carbazole Mannich bases
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DOI: 10.1007/s00044-017-1927-5
Abstract: A new class of carbazole Mannich bases were synthesized from 4-hydroxycarbazole by reacting with aromatic aldehydes and cyclic amines under mild reaction conditions in good yields. The method does not require column chromatographic purification for… read more here.
Keywords: carbazole mannich; mannich bases; vitro antiproliferative; antiproliferative activity ... See more keywords
Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new pyrazolylthiazole derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1963-1
Abstract: The development of new HIV-1 non-nucleoside reverse transcriptase inhibitors offers the possibility of generating novel structures of increased potency. Based on the bioisosteric principle, new series of N′-benzylidene-2-(5-(4-chlorophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)thiazole-4-carbohydrazide schiff bases 5a–x containing 1,3-thiazole clubbed with… read more here.
Keywords: crystal structure; hiv; antiproliferative activity; activity ... See more keywords
Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids
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DOI: 10.1007/s00044-019-02344-2
Abstract: As pharmacophore hybridization has been used frequently in the discovery of new drugs, ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids have been synthesized and evaluated their antiproliferative activity by the MTT assay. The results displayed that, the hybrids… read more here.
Keywords: thymine hybrids; glycyrrhetinic acid; ursolic acid; acid ... See more keywords
Synthesis and Antiproliferative Activity of Novel Pyranocarbazoles
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DOI: 10.1007/s10593-018-2354-3
Abstract: A new series of pyrano[3,2-c]carbazole and pyrano[2,3-a]carbazole derivatives have been synthesized by one-pot three-component coupling of 4-hydroxycarbazole or 2-hydroxycarbazole, aromatic substituted aldehydes, and (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine under microwave irradiation. This rapid one-pot reaction does not require a… read more here.
Keywords: dihydropyrano carbazol; methyl nitro; activity; cancer ... See more keywords
Characteristics of Pitaya After Radio Frequency Treating: Structure, Phenolic Compounds, Antioxidant, and Antiproliferative Activity
Sign Up to like & getrecommendations! Published in 2019 at "Food and Bioprocess Technology"
DOI: 10.1007/s11947-019-02349-0
Abstract: The performances of radio frequency (RF) heating treatment of pitaya fruits, with varying distances between the electrode plates, were investigated. The data indicated that a large gap between the electrode plates would reduce the highest… read more here.
Keywords: gap; treatment; radio frequency; antiproliferative activity ... See more keywords