New antiproliferative agents derived from tricyclic 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine scaffold: Synthesis and pharmacological effects
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200295
Abstract: A series of novel 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine (BIT) derivatives were designed and synthesized. In vitro antiproliferative activity was detected toward two human colorectal adenocarcinoma cell lines (CaCo‐2 and HT‐29) and one human dermal microvascular endothelial cell line… read more here.
Keywords: new antiproliferative; imidazo triazine; dihydrobenzo imidazo; antiproliferative agents ... See more keywords
New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200357
Abstract: A series of new 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids 9a–o and 10a–k were designed and synthesized as potential antiproliferative agents. Hybrids 9a–o exhibited remarkable antiproliferative activities on different NCI‐60 cell lines in a single‐dose assay. The antiproliferative activities… read more here.
Keywords: chalcone benzimidazole; antiproliferative agents; new oxadiazole; benzimidazole hybrids ... See more keywords
Metal NHC Complexes with Naphthalimide Ligands as DNA‐Interacting Antiproliferative Agents
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DOI: 10.1002/cmdc.201600557
Abstract: Naphthalimide‐based N‐heterocyclic carbene (NHC) complexes of the type [(1,5‐cyclooctadiene)(NHC)RhCl)] (4 a–c), [(p‐cymene)(NHC)RuCl2)] (5 a–c), and [(NHC)CuBr] (6 a–c) were synthesized and investigated as antiproliferative agents that target DNA. The cytotoxic effects were largely driven by the naphthalimide structure,… read more here.
Keywords: metal nhc; complexes naphthalimide; antiproliferative agents; ligands dna ... See more keywords
8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02730-4
Abstract: Synthetic procedures for the preparation of 8-ethynylxanthines by treating 8-bromocaffeine and 8-bromopentoxifylline with terminal acetylenes were elaborated. Certain ethynylxanthine derivatives exhibit high in vitro antiproliferative activity against a panel of cancer cell lines, matrix metalloproteinase… read more here.
Keywords: ethynylxanthines promising; antiproliferative agents; agents angiogenesis; channel ... See more keywords
Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.07.007
Abstract: In an aim at developing new antiproliferative agents, new series of benzothiazole/benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c were prepared and evaluated for their antiproliferative activity against breast carcinoma (MCF-7) and non-small… read more here.
Keywords: benzoxazole benzimidazole; antiproliferative agents; cox; benzothiazole benzoxazole ... See more keywords
Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.015
Abstract: New benzothiopyranoindoles (5a-l) and pyridothiopyranoindoles (5m-t), featuring different combinations of substituents (H, Cl, OCH3) at R2-R4 positions and protonatable R1-dialkylaminoalkyl chains, were synthesized and biologically assayed on three human tumor cell lines, showing significant antiproliferative… read more here.
Keywords: benzothiopyranoindole pyridothiopyranoindole; targeting topoisomerases; pyridothiopyranoindole based; antiproliferative agents ... See more keywords
Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.06.073
Abstract: Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin skeleton and an organoselenium motif. Three families were obtained: isoselenocyanate, selenocarbamates and selenoureas. The main purpose of these… read more here.
Keywords: selenocoumarins new; new multitarget; coumarin; silico calculations ... See more keywords
Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents.
Sign Up to like & getrecommendations! Published in 2023 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00425
Abstract: In our search for new safe antiparasitic agents, an enzymatic pathway was applied to synthesize a series of N-pyridinylmethyl amides derived from structurally different carboxylic acids. Thirty derivatives, including 11 new compounds, were prepared through… read more here.
Keywords: synthesis biological; lipase catalyzed; biological evaluation; antiproliferative agents ... See more keywords
Design, synthesis, and in silico studies of pyrazolyl-thiazole and thiazolidinone hybrids as potential antiproliferative agents
Sign Up to like & getrecommendations! Published in 2025 at "Synthetic Communications"
DOI: 10.1080/00397911.2025.2511819
Abstract: Abstract Breast and liver cancers are the most common causes of cancer death and finding new anticancer agents is critical. Inspired by their antitumor potential, thiazole and thiazolidinone derivatives bearing a pyrazole core were prepared… read more here.
Keywords: antiproliferative agents; silico studies; thiazole thiazolidinone; thiazolidinone ... See more keywords
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.
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DOI: 10.2174/1871520616666160926120904
Abstract: BACKGROUND Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression. In order to investigate on potential use of… read more here.
Keywords: par1; arylpiperazine derivatives; antiproliferative agents; protease activated ... See more keywords
Design and synthesis of new 1,2,4-oxadiazole/quinazoline-4-one hybrids with antiproliferative activity as multitargeted inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2024.1447618
Abstract: Introduction The combination of BRAF and tyrosine kinase (TK) inhibitors has been demonstrated to be highly effective in inhibiting tumor development and is an approach for overcoming resistance in clinical trials. Accordingly, a novel series… read more here.
Keywords: one hybrids; oxadiazole quinazoline; antiproliferative agents; quinazoline one ... See more keywords