Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2258-x
Abstract: Twenty-eight compounds of the type N´-substituted-2-(5-nitroheterocyclic-2-yl)-3H-benzo[d]imidazole-5-carboxamide were obtained using as an oxidizing agent the nitrobenzene to obtain the benzimidazole scaffold, a modification of the Steglich esterification reaction was used to obtain the final compounds. The… read more here.
Keywords: synthesis antimalarial; apoptotic activities; antiproliferative apoptotic; antimalarial antiproliferative ... See more keywords
Antiproliferative and apoptotic potential of methotrexate lipid nanoparticle in murine breast cancer model.
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DOI: 10.2217/nnm-2021-0446
Abstract: Aim: To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials & methods: MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular… read more here.
Keywords: cellular uptake; breast cancer; methotrexate; antiproliferative apoptotic ... See more keywords
The Antiproliferative and Apoptotic Effects of a Novel Quinazoline Carrying Substituted-Sulfonamides: In Vitro and Molecular Docking Study
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DOI: 10.3390/molecules27030981
Abstract: In order to investigate for a new effective and safe anticancer drug, we synthesized a novel series of quinazoline containing biologically active substituted-sulfonamide moiety at 3- position 4a–n. The structure of the newly prepared compounds… read more here.
Keywords: molecular docking; cell; novel quinazoline; apoptotic effects ... See more keywords
Antiproliferative and apoptotic effects of high-dose vitamin C in cholangiocarcinoma cell line
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DOI: 10.4314/tjpr.v17i6.9
Abstract: Purpose : To evaluate the antiproliferative and apoptotic effects of high-dose vitamin C in cholangiocarcinoma cell line (CCA). Methods : Sulforhodamine B colorimetric assay was used to determine cell proliferation in human K100- CCA cell… read more here.
Keywords: effects high; apoptotic effects; ascorbic acid; vitamin cholangiocarcinoma ... See more keywords