Antiproliferative effect of the histone demethylase inhibitor GSK‐J4 in chondrosarcomas
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DOI: 10.1002/iub.2110
Abstract: Chondrosarcoma (CS) is the second most common malignant bone sarcoma. Its treatment remains an issue, because this tumor is radio‐ and chemo‐resistant. In the present study, we investigated the antitumoral potential of GSK‐J4, a small… read more here.
Keywords: demethylase; antiproliferative effect; cisplatin; proliferation ... See more keywords
Antiproliferative Effect of Amaranth Proteins and Peptides on HT-29 Human Colon Tumor Cell Line
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DOI: 10.1007/s11130-018-0708-8
Abstract: Antiproliferative effect of Amaranthus mantegazzianus proteins and peptides released after simulated gastrointestinal digestion (DH% 37.8 ± 3.8) was investigated on human colon cancer cell line HT-29. Inhibition of proliferation of HT-29 cells was exhibited after a 24 h… read more here.
Keywords: cell line; proteins peptides; antiproliferative effect; effect ... See more keywords
Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics
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DOI: 10.1016/j.steroids.2017.09.013
Abstract: Graphical abstract Figure. No Caption available. HighlightsFirst reported 17&bgr;‐amide derivatives of 2‐methoxyestradiol.The single crystal X‐ray diffraction confirmed the configuration of 17&bgr;‐butyrylamino of 6c.Three derivatives had similar or even better effects than 2‐ME in antiproliferative assay.Pharmacokinetic… read more here.
Keywords: amide derivatives; bgr; derivatives methoxyestradiol; antiproliferative effect ... See more keywords
Synthesis of 6-unsubstituted 2-oxo, 2-thioxo, and 2-amino-3,4-dihydropyrimidines and their antiproliferative effect on HL-60 cells
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DOI: 10.1016/j.tetlet.2020.151967
Abstract: Abstract A general and efficient synthetic method for 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-thiones 6 and -ones 7 has been developed. In three-component reactions, the reactivity of reagents serving as the C5–C6 fragment of the dihydropyrimidine ring was compared.… read more here.
Keywords: unsubstituted oxo; antiproliferative effect; thioxo amino; effect ... See more keywords
Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152760
Abstract: Abstract An efficient method of synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines 9 has been developed. The substitution reaction of 2-methylthiodihydropyrimidines 7 and primary amines in the presence of a catalytic amount of Sc(OTf)3 with heating proceeds… read more here.
Keywords: antiproliferative effect; aminodihydropyrimidines otf; novel unsubstituted; synthesis novel ... See more keywords
The Antiproliferative Effect of the “Early” Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells
Sign Up to like & getrecommendations! Published in 2019 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672919050028
Abstract: The antiproliferative effect of the “early” protein E2 of the high-risk oncogenic human papillomavirus HPV16 on mouse testis tumors, which were induced by the intramuscular injection of HeLa cells, was discovered. The regression of tumors… read more here.
Keywords: effect early; hela cells; antiproliferative effect; testis ... See more keywords
Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22556
Abstract: Type I interferons (IFN-α/β) have broad and potent immunoregulatory and antiproliferative activities, which are negatively regulated by Src homology domain 2 containing tyrosine phosphatase-2 (SHP-2). Inhibition of SHP2 by small molecules may be a new… read more here.
Keywords: phosphatase; antiproliferative effect; effect; inhibition shp2 ... See more keywords
Seasonality Modulates the Cellular Antioxidant Activity and Antiproliferative Effect of Sonoran Desert Propolis
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DOI: 10.3390/antiox9121294
Abstract: The main chemical composition and pharmacological potential of propolis from arid and semi-arid regions of the Sonoran Desert have been previously reported. Caborca propolis (CP), from an arid zone of the Sonoran Desert, has shown… read more here.
Keywords: cellular antioxidant; antioxidant activity; antiproliferative effect; effect ... See more keywords
Chemical Composition of Volatile Extracts from Black Raspberries, Blueberries, and Blackberries and Their Antiproliferative Effect on A549 Non-Small-Cell Lung Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12122056
Abstract: Berry volatiles are responsible for the berry aroma but there is limited information available on the health-promoting activities of berry volatiles. The objectives of this study were to evaluate the chemical composition of volatile extracts… read more here.
Keywords: cell; chemical composition; antiproliferative effect; volatile extracts ... See more keywords
Cow and Ewe Cheeses Made with Saffron: Characterization of Bioactive Compounds and Their Antiproliferative Effect in Cervical Adenocarcinoma (HeLa) and Breast Cancer (MDA-MB-231) Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061995
Abstract: Saffron is a widespread consumed spice containing many phytochemicals. It is often used in dairy technologies to enhance color and flavor of cheeses, but it is also known for its several therapeutic effects, as well… read more here.
Keywords: cow ewe; bioactive compounds; crocin; antiproliferative effect ... See more keywords
Synthesis and Antiproliferative Effect of Halogenated Coumarin Derivatives
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DOI: 10.3390/molecules27248897
Abstract: A series of 6- and 6,8-halocoumarin derivatives have been investigated as potential antiproliferative compounds against a panel of tumor and normal cell lines. Cytotoxic effects were determined by the MTT method. To investigate the potential… read more here.
Keywords: effect halogenated; antiproliferative effect; effect; halogenated coumarin ... See more keywords